Home Tools
Log in
Cart

Search Result

Search Results for " blm "

Targets

7

Compounds

2

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10557 BLM-IN-1 Others
BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor (KD: 1.81 μM; IC50: 0.95 μM). It induces DNA damage response, apoptosis and proliferation arrest in cancer cells
T73391 BLM-IN-2
BLM-IN-2, a Bloom's Syndrome Protein (BLM) inhibitor, exhibits an IC50 of 0.8 μM and shows efficacy in suppressing proliferation, invasion, cell cycle arrest, and apoptosis in colorectal cancer (CRC) cells, making it a p...
T77903 Belantamab mafodotin Belantamab mafodotin-blm,GSK2857916
Belantamab mafodotin (GSK2857916) is a conjugate of a humanized, targeted monoclonal antibody directed against the B cell maturation antigen (BCMA) and the cytotoxic agent McMMAF, exhibiting anti-myeloma activity [1] [2]...
T5413 ML216 CID-49852229 DNA/RNA Synthesis
ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM).
T38709 PFM39 Others
PFM39 is a selective MRE11 nucleic acid exonuclease inhibitor and Mirin analog that prolongs mitosis.PFM39 inhibits HR and alleviates repair defects caused by EXO1/BLM depletion.
T40823 NCGC00029283 DNA/RNA Synthesis
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom synd...
T82938 ATUX-1215
ATUX-1215, a protein phosphatase 2A (PP2A) activator, diminishes the phosphorylation of ERK, p38, JNK, and Akt, as well as decreases the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals, potentially deceler...
Cat No. Product Name Synonyms Targets
T4953 Neotuberostemonine NOS
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruit...
TN3469 Aucuparin 2,6-dimethoxy-4-phenylphenol NADPH-oxidase
Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging act...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01010 BLM Protein, Human, Recombinant (His) Human E. coli
BLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.0 kDa and the accession number is P54132.
TMPH-02550 BLM Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
BLM Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.7 kDa and the accession number is O88700.
TMPY-01865 BLMH Protein, Mouse, Recombinant (His) Mouse E. coli
The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide...
TargetMol