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Search Result

Search Results for " bcl-w "

Targets

Mitophagy BCL Autophagy

7

Compounds

1

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2099 ABT-737 Mitophagy , BCL , Autophagy
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T2101 Navitoclax ABT-263 BCL
Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activity and induces apoptosis.
T6748 A-1155463 A 1155463,A1155463 BCL
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
T2119 Venetoclax GDC-0199,ABT 199,ABT-199,ABT199 BCL , Autophagy
Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces a...
T40230 Mcl-1 inhibitor 6
Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compou...
T76073 BH3 hydrochloride
BH3 hydrochloride, a peptide that crosses the blood-brain barrier, induces apoptosis either through direct activation of the pro-apoptotic proteins Bax/Bak or by inhibiting anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, B...
T6749 A-1331852 BCL
A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.
Cat No. Product Name Synonyms Targets
T6185 Gambogic Acid Beta-Guttiferrin,Guttatic Acid,Guttic Acid BCL , Autophagy
Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 ...

Natural Products

Gambogic Acid
T6185
Synonym: Beta-Guttiferrin,Guttatic Acid,Guttic Acid
Target: BCL, Autophagy

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (2)
Tag：
C-6xHis (1)
His (1)
Cat No. Product Name Species Expression System
TMPY-02004 BCL-W Protein, Human, Recombinant (His) Human E. coli
BCL-W Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20 kDa and the accession number is Q92843-1.
TMPJ-00584 Bc1-w Protein, Human, Recombinant (His) Human E. coli
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre...
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