ache-in-5 — TargetMol Chemicals

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Search Results for " ache-in-5 "

Compounds

Cat No.	Product Name	Synonyms	Targets
T64162	AChE-IN-5
	AChE-IN-5 (compound 5) is an orally active, blood-brain barrier-transparent substance with significant in vitro biological activity against AChE/5-HT1A/SERT. IC50: 2.29 nM).
T60721	AChE/BChE-IN-5
	AChE/BChE-IN-5 (BMC-16) is an AChE and BChE dual inhibitor that can cross the BBB. The IC 50 values of AChE/BChE-IN-5 for human AChE (hAChE) and human BChE (hBChE) are 266 nM and 10.6 nM , respectively [1].
T5S2343	Acetylshikonin	Acetyl shikonin	Others , P450 , AChE
	1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...		Others , P450 , AChE
T72893	AChE/MAO-IN-2
	Dual AChE-MAO B-IN-5, an indanone derivative, serves as an effective dual inhibitor for AChE and MAO-B, displaying IC50 values of 0.0224 μM for AChE, 0.0412 μM for MAO-B, and 0.1116 μM for MAO-A. Additionally, it exhibit...
T61178	Aβ-IN-5
	Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effec...
T62046	HDAC6-IN-5
	HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowt...
T64102	HCAI/II-IN-5
	hCAI/II-IN-5 is a potent inhibitor of hCA I and hCA II (human carbonic anhydrase isozymes I and II), with IC50 values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also inhibits α-Glycosidase (IC50: 48.98 nM) and ACh...
T63215	COX-2-IN-22
	COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ...
T36639	Donecopride (fumarate hydrate)
	Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ...
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch...
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids...
T73930	(-)-Eseroline fumarate
	(-)-Eseroline fumarate, a metabolite of the acetylcholinesterase inhibitor Physostigmine, promotes lactic acid dehydrogenase (LDH) leakage from cancer cells and triggers adenine nucleotides and 5-hydroxytryptamine (5-HT)...