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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6319 | OSI-027 | ASP4786,OSI027 | DNA-PK , PI3K , mTOR , Autophagy |
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1. |