Vascular Endothelial Growth Factor Receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding. In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. Inhibitors of VEGFR are used in the treatment of cancer.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPY-04795 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.9 kDa and th... | |||
TMPY-04796 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the ... | |||
TMPY-04802 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.4 kDa and the ... | |||
TMPY-04924 | VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated
VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated
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Mouse | HEK293 Cells |
VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and th... | |||
TMPY-04940 | VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and th... | |||
TMPY-05382 | VEGFR2/KDR Protein, Cynomolgus, Recombinant (His)
VEGFR2/KDR Protein, Cynomolgus, Recombinant (His)
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Cynomolgus | HEK293 Cells |
VEGFR2/KDR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.7 kDa and the accessi... | |||
TMPY-05610 | VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 8... | |||
TMPY-05657 | VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and th... | |||
TMPY-05733 | FLT1 Protein, Mouse, Recombinant (His)
FLT1 Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
FLT1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number i... | |||
TMPY-06620 | VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 Cells |
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is ... | |||
TMPY-06665 | FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
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Mouse | HEK293 Cells |
FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 88.34 k... | |||
TMPY-06780 | FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 Cells |
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 85.45 k... | |||
TMPY-01936 | VEGFR3/FLT4 Protein, Mouse, Recombinant (His)
VEGFR3/FLT4 Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
VEGFR3/FLT4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession n... | |||
TMPY-00637 | FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His)
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Human | HEK293 Cells |
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accessio... | |||
TMPY-00949 | VEGFR3/FLT4 Protein, Human, Recombinant (His)
VEGFR3/FLT4 Protein, Human, Recombinant (His)
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Human | HEK293 Cells |
VEGFR3/FLT4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession num... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His)
VEGFR2/KDR Protein, Human, Recombinant (His)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession nu... | |||
TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protei... |