Vascular Endothelial Growth Factor Receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding. In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. Inhibitors of VEGFR are used in the treatment of cancer.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPJ-00414 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular ... | |||
TMPJ-00593 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa an... | |||
TMPK-00445 | VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
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Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi... | |||
TMPK-00446 | VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
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Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi... | |||
TMPK-00450 | VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
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Human | HEK293 Cells |
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 85.1 kDa and th... | |||
TMPK-00451 | VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 Cells |
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8... | |||
TMPK-00454 | VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
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Human | HEK293 Cells |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t... | |||
TMPK-00645 | VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
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Rhesus | HEK293 Cells |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t... | |||
TMPY-00119 | FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number i... | |||
TMPY-01044 | VEGFR2/KDR Protein, Human, Recombinant (hFc)
VEGFR2/KDR Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 109 kDa and the accession num... | |||
TMPY-01069 | VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
VEGFR3/FLT4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.3 kDa and the accession ... | |||
TMPY-01937 | VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
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Mouse | HEK293 Cells |
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112 kDa and the accession nu... | |||
TMPY-02108 | FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His)
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Human | HEK293 Cells |
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accessio... | |||
TMPY-02678 | VEGFR2/KDR Protein, Rat, Recombinant (His)
VEGFR2/KDR Protein, Rat, Recombinant (His)
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Rat | HEK293 Cells |
VEGFR2/KDR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.3 kDa and the accession numb... | |||
TMPY-02736 | VEGFR2/KDR Protein, Mouse, Recombinant (His)
VEGFR2/KDR Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
VEGFR2/KDR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession nu... | |||
TMPY-02858 | VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
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Mouse | HEK293 Cells |
VEGFR2/KDR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession num... | |||
TMPY-03202 | VEGFR2/KDR Protein, Rat, Recombinant (hFc)
VEGFR2/KDR Protein, Rat, Recombinant (hFc)
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Rat | HEK293 Cells |
VEGFR2/KDR Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession numbe... | |||
TMPY-03299 | FLT1 Protein, Rat, Recombinant (His)
FLT1 Protein, Rat, Recombinant (His)
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Rat | HEK293 Cells |
FLT1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84 kDa and the accession number is P5... | |||
TMPY-04530 | VEGFR2/KDR Protein, Human, Recombinant (His & GST)
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
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Human | Baculovirus Insect Cells |
VEGFR2/KDR Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.3 kDa and ... | |||
TMPY-04794 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
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Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and th... |