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Vascular Endothelial Growth Factor Receptors, VEGFRs

Vascular Endothelial Growth Factor Receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding. In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. Inhibitors of VEGFR are used in the treatment of cancer.

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Species
Cynomolgus (1)
Human (25)
Mouse (7)
Rat (3)
Rhesus (1)
Expression System
Baculovirus Insect Cells (1)
HEK293 Cells (36)
Tag
Avi (1)
C-6xHis (1)
C-6xHis-Avi (1)
C-Avi-His (1)
C-His (15)
C-His-Avi (7)
C-hFc (10)
GST (1)
His (2)
Cat No. product name / Synonyms Species Expression System
TMPJ-00414 VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
Human HEK293 Cells
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular ...
TMPJ-00593 VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
Human HEK293 Cells
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa an...
TMPK-00445 VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
TMPK-00446 VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
Human HEK293 Cells
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
TMPK-00450 VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 85.1 kDa and th...
TMPK-00451 VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8...
TMPK-00454 VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
TMPK-00645 VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
Rhesus HEK293 Cells
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
TMPY-00119 FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number i...
TMPY-01044 VEGFR2/KDR Protein, Human, Recombinant (hFc)
VEGFR2/KDR Protein, Human, Recombinant (hFc)
Human HEK293 Cells
VEGFR2/KDR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 109 kDa and the accession num...
TMPY-01069 VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
VEGFR3/FLT4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.3 kDa and the accession ...
TMPY-01937 VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112 kDa and the accession nu...
TMPY-02108 FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His)
Human HEK293 Cells
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accessio...
TMPY-02678 VEGFR2/KDR Protein, Rat, Recombinant (His)
VEGFR2/KDR Protein, Rat, Recombinant (His)
Rat HEK293 Cells
VEGFR2/KDR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.3 kDa and the accession numb...
TMPY-02736 VEGFR2/KDR Protein, Mouse, Recombinant (His)
VEGFR2/KDR Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
VEGFR2/KDR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession nu...
TMPY-02858 VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
VEGFR2/KDR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession num...
TMPY-03202 VEGFR2/KDR Protein, Rat, Recombinant (hFc)
VEGFR2/KDR Protein, Rat, Recombinant (hFc)
Rat HEK293 Cells
VEGFR2/KDR Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession numbe...
TMPY-03299 FLT1 Protein, Rat, Recombinant (His)
FLT1 Protein, Rat, Recombinant (His)
Rat HEK293 Cells
FLT1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84 kDa and the accession number is P5...
TMPY-04530 VEGFR2/KDR Protein, Human, Recombinant (His & GST)
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
Human Baculovirus Insect Cells
VEGFR2/KDR Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.3 kDa and ...
TMPY-04794 VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
Human HEK293 Cells
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and th...
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
TMPJ-00414
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular ...
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
TMPJ-00593
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa an...
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
TMPK-00445
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
TMPK-00446
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
TMPK-00450
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 85.1 kDa and th...
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00451
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8...
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
TMPK-00454
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
TMPK-00645
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
FLT1 Protein, Human, Recombinant (hFc)
TMPY-00119
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number i...
VEGFR2/KDR Protein, Human, Recombinant (hFc)
TMPY-01044
VEGFR2/KDR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 109 kDa and the accession num...
VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
TMPY-01069
VEGFR3/FLT4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.3 kDa and the accession ...
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
TMPY-01937
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112 kDa and the accession nu...
FLT1 Protein, Human, Recombinant (aa 1-756, His)
TMPY-02108
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accessio...
VEGFR2/KDR Protein, Rat, Recombinant (His)
TMPY-02678
VEGFR2/KDR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.3 kDa and the accession numb...
VEGFR2/KDR Protein, Mouse, Recombinant (His)
TMPY-02736
VEGFR2/KDR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession nu...
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
TMPY-02858
VEGFR2/KDR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession num...
VEGFR2/KDR Protein, Rat, Recombinant (hFc)
TMPY-03202
VEGFR2/KDR Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession numbe...
FLT1 Protein, Rat, Recombinant (His)
TMPY-03299
FLT1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84 kDa and the accession number is P5...
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
TMPY-04530
VEGFR2/KDR Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.3 kDa and ...
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
TMPY-04794
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and th...
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TargetMol