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Vascular Endothelial Growth Factor Receptors, VEGFRs

Vascular Endothelial Growth Factor Receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding. In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. Inhibitors of VEGFR are used in the treatment of cancer.

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Species
Cynomolgus (1)
Human (25)
Mouse (7)
Rat (3)
Rhesus macaque (1)
Expression System
Baculovirus-Insect Cells (1)
HEK293 (33)
Human Cells (3)
Tag
AVI (4)
C-6His (1)
C-6His-Avi (1)
C-Fc (1)
C-His (1)
C-His-Avi (5)
GST (1)
His (19)
hFc (9)
Cat No. product name / Synonyms Species Expression System
TMPJ-00414 VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
Human Human Cells
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in ...
TMPJ-00593 VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
Human Human Cells
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in ...
TMPK-00445 VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
Human HEK293
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
TMPK-00446 VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
Human HEK293
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
TMPK-00450 VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
Human HEK293
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class...
TMPK-00451 VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class...
TMPK-00454 VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
Human HEK293
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
TMPK-00645 VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
Rhesus macaque HEK293
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
TMPY-00119 FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc)
Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F...
TMPY-01044 VEGFR2/KDR Protein, Human, Recombinant (hFc)
VEGFR2/KDR Protein, Human, Recombinant (hFc)
Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
TMPY-01069 VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
Human HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept...
TMPY-01937 VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
Mouse HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept...
TMPY-02108 FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His)
Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F...
TMPY-02678 VEGFR2/KDR Protein, Rat, Recombinant (His)
VEGFR2/KDR Protein, Rat, Recombinant (His)
Rat HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
TMPY-02736 VEGFR2/KDR Protein, Mouse, Recombinant (His)
VEGFR2/KDR Protein, Mouse, Recombinant (His)
Mouse HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
TMPY-02858 VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
Mouse HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
TMPY-03202 VEGFR2/KDR Protein, Rat, Recombinant (hFc)
VEGFR2/KDR Protein, Rat, Recombinant (hFc)
Rat HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
TMPY-03299 FLT1 Protein, Rat, Recombinant (His)
FLT1 Protein, Rat, Recombinant (His)
Rat HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F...
TMPY-04530 VEGFR2/KDR Protein, Human, Recombinant (His & GST)
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
Human Baculovirus-Insect Cells
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
TMPY-04794 VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
TMPJ-00414
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in ...
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
TMPJ-00593
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in ...
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
TMPK-00445
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
TMPK-00446
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosi...
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
TMPK-00450
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class...
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00451
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class...
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
TMPK-00454
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
TMPK-00645
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, t...
FLT1 Protein, Human, Recombinant (hFc)
TMPY-00119
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F...
VEGFR2/KDR Protein, Human, Recombinant (hFc)
TMPY-01044
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
TMPY-01069
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept...
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
TMPY-01937
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are recept...
FLT1 Protein, Human, Recombinant (aa 1-756, His)
TMPY-02108
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F...
VEGFR2/KDR Protein, Rat, Recombinant (His)
TMPY-02678
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
VEGFR2/KDR Protein, Mouse, Recombinant (His)
TMPY-02736
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
TMPY-02858
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
VEGFR2/KDR Protein, Rat, Recombinant (hFc)
TMPY-03202
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
FLT1 Protein, Rat, Recombinant (His)
TMPY-03299
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor F...
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
TMPY-04530
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
TMPY-04794
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restr...
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TargetMol