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Xyloidone

Catalog No. T19962 CAS 15297-92-4

Synonyms: NSC-106453, NSC106453, Dehydro-α-lapachone, NSC 106453, Dehydrolapachone, NSC 629748

Xyloidone (NSC-106453) exhibits antifungal activity and completely inhibits the mycelial growth of B. cinerea, Colletotrichum acutatum Simmonds, Colletotrichum gloeosporioides Simmonds, M. grisea, and Pythium ultimum Trow over a range of 0.4-33.3 mg/L.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Xyloidone, CAS 15297-92-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 269.00
10 mg	In stock	$ 395.00
25 mg	In stock	$ 659.00
50 mg	In stock	Inquiry

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Purity: 98.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Xyloidone (NSC-106453) exhibits antifungal activity and completely inhibits the mycelial growth of B. cinerea, Colletotrichum acutatum Simmonds, Colletotrichum gloeosporioides Simmonds, M. grisea, and Pythium ultimum Trow over a range of 0.4-33.3 mg/L.
In vitro	Xyloidone controlls the development of rice blast, tomato late blight, wheat leaf rust, barley powdery mildew and red pepper anthracnose (Colletotrichum coccodes (Wallr) S Hughes). Xyloidone is particularly effective in suppressing red pepper anthracnose by 95% at a concentration of 125 mg/L[1].
In vivo	Xyloidone inhibits vessel regeneration, interferes with vessel anastomosis, and limits plexus formation in zebrafish. Xyloidone induces vascular pruning and growth delay in orthotopic mammary tumors in mice. Xyloidone targets cell adhesion by promoting ubiquitination of the Rho-GTPase Rac1, which is frequently up-regulated in many different cancers[1].

Synonyms	NSC-106453, NSC106453, Dehydro-α-lapachone, NSC 106453, Dehydrolapachone, NSC 629748
Molecular Weight	240.25
Formula	C15H12O3
CAS No.	15297-92-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Moraes DC, et al. β-lapachone and α-nor-lapachone modulate Candida albicans viability and virulence factors. J Mycol Med. 2018 Mar 26. pii: S1156-5233(17)30379-7. 2. Garkavtsev I, et al. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11596-601. 3. Cho JY, et al. Dehydro-alpha-lapachone isolated from Catalpa ovata stems: activity against plant pathogenic fungi. Pest Manag Sci. 2006 May;62(5):414-8. 4. Otten S, Rosazza JP. Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata. Appl Environ Microbiol. 1979 Aug;38(2):311-3.

Related compound libraries

This product is contained In the following compound libraries：

Natural Product Library for HTS RO5 Drug-like Natural Product Library

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Keywords

Xyloidone 15297-92-4 Microbiology/Virology Antifungal NSC-106453 NSC106453 NSC629748 Dehydro-α-lapachone NSC-629748 Dehydro-a-lapachone Dehydro-alpha-lapachone NSC 106453 Dehydrolapachone NSC 629748 inhibitor inhibit

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