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Cedrol

Catalog No. T5594   CAS 77-53-2

Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)

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Cedrol Chemical Structure
Cedrol, CAS 77-53-2
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500 mg In stock $ 37.00
1 mL * 10 mM (in DMSO) In stock $ 29.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)
Targets&IC50 CYP2B6:3.4 Μm(ki), CYP3A4:0.9μM(ki)
In vitro Cedrol inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi when used at a concentration of 100 μg/ml[1].Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)[2].
In vivo In vivo, cedrol (200 mg/kg) prevents hair follicle dystrophy and reduces hair loss in a mouse model of alopecia induced by cyclophosphamide[3]
Cell Research The inhibitory potencies (IC50 values) of β-cedrene, cedrol, thujopsene, and a CYP2B6 inhibitor, thioTEPA, of CYP2B6- catalyzed bupropion hydroxylase activity were evaluated in pooled human liver microsomes and cDNA-expressed CYP2B6 using LCMS/MS.?Incubation mixtures were prepared in a total volume of 100 μl, including 1 mM NADPH, 10 mM MgCl2, 50 mM potassium phosphate buffer (pH 7.4), various concentrations of β-cedrene, cedrol, thujopsene, or thioTEPA, pooled human liver microsomes (0.2 mg/ml) or human cDNA-expressed CYP2B6 (0.4 pmol), and a CYP2B6-selective substrate 50 μM bupropion.?After a 3-min preincubation at 37℃, the reactions were initiated by adding NADPH and were incubated for 15 min at 37 C in a shaking water bath.?The reaction was terminated by placing tubes on ice and adding 100 μl icecold d9-1 -hydroxybufuralol (internal standard) in methanol.?Incubation mixtures were then centrifuged at 13,000×g for 4 min at 4℃.?All incubations were performed in triplicate, and average values were used.?To evaluate NADPH-dependent mechanism-based inhibition, various concentrations of β-cedrene, cedrol, thujopsene, and thioTEPA were preincubated for 30 min with pooled human liver microsomes in the presence of NADPH.?The reaction was started by bupropion addition[2].
Animal Research Acute toxicity, skin irritation and skin sensitization tests of cedrol were conducted before the experiment, which suggested that cedrol had hardly toxic and side effects.Three different doses of cedrol prepared in 85% ethanol were spread on the dorsal skin of mice 2 days after depilation for several consecutive days until the mice were all sacrificed under an ether atmosphere to evaluate whether topical treatment with cedrol may prevent or alleviate CYP-induced alopecia[3].
Molecular Weight 222.37
Formula C15H26O
CAS No. 77-53-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44 mg/mL (197.86 mM)

TargetMolReferences and Literature

1. CHENG, SenSung, CHUNG, et al. Phytochemicals from Cunninghamia konishii Hayata Act as Antifungal Agents[J]. Journal of Agricultural & Food Chemistry, 2012, 60(1):124-8. 2. Jeong H U , Kwon S S , Kong T Y , et al. Inhibitory Effects of Cedrol, β-Cedrene, and Thujopsene on Cytochrome P450 Enzyme Activities in Human Liver Microsomes[J]. Journal of Toxicology and Environmental Health, Part A, 2014, 77(22-24):1522-1532. 3. Chen S S , Zhang Y , Lu Q L , et al. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice[J]. Environ Toxicol Pharmacol, 2016, 46:270-276.

TargetMolCitations

1. Özek G, Schepetkin I A, Yermagambetova M, et al. Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species. Molecules. 2021, 26(24): 7644.

Related compound libraries

This product is contained In the following compound libraries:
Antiparasitic Natural Product Library Tibetan medicine Compound Library Food Additive Library Food as Medicine Compound Library Anti-Fungal Compound Library Anti-Hypertension Compound Library Marine Natural Product Library Microbial Natural Product Library Miao medicine Compound Library Tobacco Monomer Library

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Keywords

Cedrol 77-53-2 Metabolism Microbiology/Virology P450 Antifungal α-Cedrol inhibit Fungal (+)-Cedrol CYPs Cytochrome P450 Inhibitor inhibitor

 

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