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Terbinafine hydrochloride

Terbinafine hydrochloride
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Purity:99.89%
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Terbinafine hydrochloride

Catalog No. T1411Cas No. 78628-80-5
Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.
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Pack SizePrice/USDAvailabilityQuantity
25 mg$30In Stock
50 mg$39In Stock
100 mg$53In Stock
200 mg$90In Stock
1 mL x 10 mM (in DMSO)$57In Stock
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Product Introduction

Bioactivity
Description
Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.
In vitro
Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5]
In vivo
Terbinafine demonstrates efficacy both as a topical application and through oral administration in experimental dermatophytoses. Notably, in guinea pigs infected with fungi, a significant decrease in skin temperature is observed after the fourth terbinafine treatment[6].
AliasKWD 2019, Terbinafine HCl, TDT 067 hydrochloride
Chemical Properties
Molecular Weight327.89
FormulaC21H26ClN
Cas No.78628-80-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 32.8 mg/mL (100 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0498 mL15.2490 mL30.4980 mL152.4902 mL
5 mM0.6100 mL3.0498 mL6.0996 mL30.4980 mL
10 mM0.3050 mL1.5249 mL3.0498 mL15.2490 mL
20 mM0.1525 mL0.7625 mL1.5249 mL7.6245 mL
50 mM0.0610 mL0.3050 mL0.6100 mL3.0498 mL
100 mM0.0305 mL0.1525 mL0.3050 mL1.5249 mL

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