Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 54.00 | |
10 mg | In stock | $ 87.00 | |
25 mg | In stock | $ 185.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 555.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
Targets&IC50 | mGluR5:30 nM(EC50) |
In vitro | VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. [1] VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. [2] |
Molecular Weight | 305.32 |
Formula | C17H17F2NO2 |
CAS No. | 433967-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 30.5 mg/mL (100 mM)
DMSO: 30.5 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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VU 0357121 433967-28-3 Neuroscience GluR inhibit Inhibitor VU-0357121 VU0357121 Metabotropic glutamate receptors mGluR inhibitor