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VU 0357121

Catalog No. T6725   CAS 433967-28-3

VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.

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VU 0357121 Chemical Structure
VU 0357121, CAS 433967-28-3
Pack Size Availability Price/USD Quantity
5 mg In stock $ 54.00
10 mg In stock $ 87.00
25 mg In stock $ 185.00
50 mg In stock $ 369.00
100 mg In stock $ 555.00
1 mL * 10 mM (in DMSO) In stock $ 54.00
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Purity: 99.99%
Purity: 99%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
Targets&IC50 mGluR5:30 nM(EC50)
In vitro VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. [1] VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. [2]
Molecular Weight 305.32
Formula C17H17F2NO2
CAS No. 433967-28-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30.5 mg/mL (100 mM)

DMSO: 30.5 mg/mL (100 mM)

TargetMolReferences and Literature

1. Hammond AS, et al. ACS Chem Neurosci, 2010, 1(10), 702-716. 2. Gregory KJ, et al. Mol Pharmacol, 2012 Aug 3.

Related compound libraries

This product is contained In the following compound libraries:
Fluorochemical Library Neuronal Signaling Compound Library Bioactive Compound Library GPCR Compound Library Target-Focused Phenotypic Screening Library Neurotransmitter Receptor Compound Library Glutamine Metabolism Compound Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Keywords

VU 0357121 433967-28-3 Neuroscience GluR inhibit Inhibitor VU-0357121 VU0357121 Metabotropic glutamate receptors mGluR inhibitor

 

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