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Treosulfan

Catalog No. T17159   CAS 299-75-2
Synonyms: NSC 39069, Treosulphan

Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.

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Treosulfan Chemical Structure
Treosulfan, CAS 299-75-2
Pack Size Availability Price/USD Quantity
2 mg In stock $ 34.00
5 mg In stock $ 55.00
10 mg In stock $ 89.00
25 mg In stock $ 178.00
50 mg In stock $ 322.00
100 mg In stock $ 572.00
500 mg In stock $ 1,190.00
1 mL * 10 mM (in DMSO) In stock $ 61.00
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Purity: 99.26%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
In vitro Treosulfan inhibits several cancer cell lines, such as Panc-1, Miapaca-2 and Capan-2 cells (IC50s: 3.6 μg/mL, 1.8 μg/mL and 2.1 μg/mL respectively). It also shows nearly 100% cytotoxicity on these cell lines at 100 μg/mL. Treosulfan (1, 2.5, 5 μg/ml) combined with 5-FU (0.1, 0.25, 0.5 μg/ml) has antagonistic effect on Panc-1 cells at intermediate and high concentrations, and on Miapaca-2 cells at all doses. Treosulfan (0.1-100 μg/mL) in combination with LY 188011 exhibits enhanced activity against cancer cells. Treosulfan (800 μg/mL) dramatically decreases erythrocyte forward scatter, increases the percentage of annexin-V-binding cells, [Ca2+]i, and ROS [1][2].
In vivo Treosulfan (1.5 g/kg/day) induces only interleukin-2 production in spleen cells for a short time. Treosulfan (1.5 g/kg/day) causes a rapid myeloablation, depletes the splenic B and T cells in mice [3].
Synonyms NSC 39069, Treosulphan
Molecular Weight 278.3
Formula C6H14O8S2
CAS No. 299-75-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (359.32 mM)

H2O: 50 mg/mL (179.66 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Nitsch E, et al. Synergistic cytotoxic activity of treosulfan and LY 188011 in pancreatic cancer cell lines. Anticancer Res. 2014 Apr;34(4):1779-84. 2. Peter T, et al. Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem. 2015;35(4):1372-80. 3. Sjöö F, et al. Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006 Jan;34(1):115-21.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library EMA Approved Drug Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library ReFRAME Related Library DNA Damage & Repair Compound Library Approved Drug Library

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Keywords

Treosulfan 299-75-2 DNA Damage/DNA Repair DNA Alkylator/Crosslinker DNA Alkylation inhibit NSC-39069 NSC 39069 Inhibitor Treosulphan NSC39069 inhibitor

 

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