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Treosulfan

Catalog No. T17159 CAS 299-75-2

Synonyms: Treosulphan, NSC 39069, 曲奥舒凡

Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.

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Treosulfan, CAS 299-75-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
In vitro	Treosulfan inhibits several cancer cell lines, such as Panc-1, Miapaca-2 and Capan-2 cells (IC50s: 3.6 μg/mL, 1.8 μg/mL and 2.1 μg/mL respectively). It also shows nearly 100% cytotoxicity on these cell lines at 100 μg/mL. Treosulfan (1, 2.5, 5 μg/ml) combined with 5-FU (0.1, 0.25, 0.5 μg/ml) has antagonistic effect on Panc-1 cells at intermediate and high concentrations, and on Miapaca-2 cells at all doses. Treosulfan (0.1-100 μg/mL) in combination with LY 188011 exhibits enhanced activity against cancer cells. Treosulfan (800 μg/mL) dramatically decreases erythrocyte forward scatter, increases the percentage of annexin-V-binding cells, [Ca2+]i, and ROS [1][2].
In vivo	Treosulfan (1.5 g/kg/day) induces only interleukin-2 production in spleen cells for a short time. Treosulfan (1.5 g/kg/day) causes a rapid myeloablation, depletes the splenic B and T cells in mice [3].

Synonyms	Treosulphan, NSC 39069, 曲奥舒凡
Molecular Weight	278.3
Formula	C6H14O8S2
CAS No.	299-75-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (359.32 mM)

H2O: 50 mg/mL (179.66 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nitsch E, et al. Synergistic cytotoxic activity of treosulfan and LY 188011 in pancreatic cancer cell lines. Anticancer Res. 2014 Apr;34(4):1779-84. 2. Peter T, et al. Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem. 2015;35(4):1372-80. 3. Sjöö F, et al. Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006 Jan;34(1):115-21.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Drug-induced Liver Injury (DILI) Compound Library DNA Damage & Repair Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Approved Drug Library Anti-Cancer Drug Library FDA-Approved & Pharmacopeia Drug Library

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Related compounds with same targets

Methyl methanesulfonate O6-Benzylguanine Satraplatin Palifosfamide Miriplatin hydrate Duocarmycin Analog VAL-083 Lobaplatin

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Keywords

Treosulfan 299-75-2 DNA损伤和修复 DNA Alkylation DNA Alkylator/Crosslinker inhibit NSC 39069 Inhibitor NSC39069 Treosulphan NSC-39069 inhibitor

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