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Treosulfan
🥰Excellent
Catalog No. T17159Cas No. 299-75-2
Alias Treosulphan, NSC 39069
Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]
Treosulfan
🥰Excellent
Purity: 99.75%
Catalog No. T17159Alias Treosulphan, NSC 39069Cas No. 299-75-2
Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $53 | In Stock | |
| 25 mg | $107 | In Stock | |
| 50 mg | $193 | In Stock | |
| 100 mg | $343 | In Stock | |
| 200 mg | $479 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock |
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Purity:99.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2] |
| In vitro | METHODS: ES cell lines A4573, CHP-100, JR (NCI-EWS 94), RD-ES, SK-N-MC, TC32, and TC71 were treated with Treosulfan (NSC 39069)(1, 10, 100, 1000 μM), and cell viability was measured by MTT assay. RESULTS The IC50 values of A4573, CHP-100, JR (NCI-EWS 94), RD-ES, SK-N-MC, TC32, and TC71 were (35, 70, 100, 250, 75, 5, 50, 10 μM). [1] |
| In vivo | METHODS: NOD/SCID mice were injected with ES sarcoma cell line TC71 or CHP-100 in the left gastrocnemius muscle. When tumors were palpable, mice were injected with Treosulfan (NSC 39069) (3,000 mg/kg, i.p), busulfan (60 mg/kg, i.p), or vehicle (PBS/20% DMSO, i.p). RESULTS Treosulfan significantly inhibited tumor growth in both cell lines, whereas busulfan only caused an initial inhibition of tumor growth in the cell line TC71 and caused tumor growth in mice injected with the cell line CHP-100 on day 13 Moderately suppressed. [1] |
| Alias | Treosulphan, NSC 39069 |
| Molecular Weight | 278.3 |
| Formula | C6H14O8S2 |
| Cas No. | 299-75-2 |
| Smiles | CS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O |
| Relative Density. | 1.305 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (359.32 mM), Sonication is recommended. H2O: 50 mg/mL (179.66 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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