Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
Description | Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types. |
In vitro | Treosulfan inhibits several cancer cell lines, such as Panc-1, Miapaca-2 and Capan-2 cells (IC50s: 3.6 μg/mL, 1.8 μg/mL and 2.1 μg/mL respectively). It also shows nearly 100% cytotoxicity on these cell lines at 100 μg/mL. Treosulfan (1, 2.5, 5 μg/ml) combined with 5-FU (0.1, 0.25, 0.5 μg/ml) has antagonistic effect on Panc-1 cells at intermediate and high concentrations, and on Miapaca-2 cells at all doses. Treosulfan (0.1-100 μg/mL) in combination with LY 188011 exhibits enhanced activity against cancer cells. Treosulfan (800 μg/mL) dramatically decreases erythrocyte forward scatter, increases the percentage of annexin-V-binding cells, [Ca2+]i, and ROS [1][2]. |
In vivo | Treosulfan (1.5 g/kg/day) induces only interleukin-2 production in spleen cells for a short time. Treosulfan (1.5 g/kg/day) causes a rapid myeloablation, depletes the splenic B and T cells in mice [3]. |
Synonyms | Treosulphan, NSC 39069, 曲奥舒凡 |
Molecular Weight | 278.3 |
Formula | C6H14O8S2 |
CAS No. | 299-75-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 100 mg/mL (359.32 mM)
H2O: 50 mg/mL (179.66 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Treosulfan 299-75-2 DNA损伤和修复 DNA Alkylation DNA Alkylator/Crosslinker inhibit NSC 39069 Inhibitor NSC39069 Treosulphan NSC-39069 inhibitor