Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 76.00 | |
25 mg | In stock | $ 119.00 | |
50 mg | In stock | $ 162.00 | |
100 mg | In stock | $ 216.00 | |
200 mg | In stock | $ 279.00 | |
500 mg | In stock | $ 468.00 |
Description | Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. |
In vitro | Tipiracil has an antiangiogenic effect that also inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2]. |
Kinase Assay | In vitro kinase inhibition assays: Kinase activity for PI3K isoforms is measured as the percentage of ATP consumed following the kinase reaction using luciferase–luciferin-coupled chemiluminescence, with ATP concentrations approximately equal to the Km for each respective kinase. Kinase reactions are initiated by combining test compounds, ATP and kinase in a 20 μL volume. PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ final enzyme concentrations are 0.5, 8, 20, and 2 nM, respectively. Of note, 0.5 μL dimethyl sulfoxide (DMSO) containing varying concentrations of the test compound is mixed with 10 μL enzyme solution (2×concentration). Kinase reactions are initiated by the addition of 10 μL of liver phosphatidylinositol and ATP solution (2×concentration). Assay concentrations for VPS34, ATP, and phosphatidylinositol are 40 nM, 1 μM, and 5 μM, respectively |
Synonyms | MA-1 hydrochloride |
Molecular Weight | 279.12 |
Formula | C9H12Cl2N4O2 |
CAS No. | 183204-72-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL(179.13 mM)
DMSO: 50 mg/mL (179.13 mM)
You can also refer to dose conversion for different animals. More
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Tipiracil hydrochloride 183204-72-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog Inhibitor Tipiracil inhibit MA-1 hydrochloride MA 1 Hydrochloride MA-1 Hydrochloride MA1 Hydrochloride Tipiracil Hydrochloride inhibitor