Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
200 mg | In stock | $ 29.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. |
Targets&IC50 | P2 receptor:2 μM |
In vitro | Oral administration of Ticlopidine HCl in rats enhances the affinity of cyclase on platelet membranes for prostaglandin E1, subsequently activating both the basal and prostaglandin E1-stimulated without affecting the enzyme activity induced by adenosine or sodium fluoride. Ticlopidine HCl exhibits an inhibitory effect on platelet aggregation with an IC50 of 2 μM in males. |
In vivo | Ticlopidine HCl inhibits platelet aggregation by activating basal PGE1-induced cyclase activity, blocking the enhancement of cyclase activity induced by PGE2, thereby increasing platelet c-AMP levels, and suppressing prostaglandin synthesis from endogenous substrates. Additionally, it alters platelet membrane function and inhibits aggregation through the blockade of ADP receptors. |
Synonyms | Ticlodone, Ticlopidine HCl, Ticlodix |
Molecular Weight | 300.25 |
Formula | C14H15Cl2NS |
CAS No. | 53885-35-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30 mg/mL (100 mM)
DMSO: 30 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
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