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Tenofovir alafenamide

Catalog No. T2409   CAS 379270-37-8
Synonyms: GS-7340

Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.

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Tenofovir alafenamide Chemical Structure
Tenofovir alafenamide, CAS 379270-37-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 45.00
10 mg In stock $ 63.00
25 mg In stock $ 88.00
50 mg In stock $ 126.00
100 mg In stock $ 171.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.97%
Purity: 99.76%
Purity: 99.75%
Purity: 99%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
In vitro GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3]
In vivo In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2]
Synonyms GS-7340
Molecular Weight 476.47
Formula C21H29N6O5P
CAS No. 379270-37-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 88 mg/mL (184.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 88 mg/mL (184.7 mM)

TargetMolReferences and Literature

1. Chapman H, et al. Nucleosides Nucleotides Nucleic Acids. 2001, 20(4-7), 1085-10[90. 2. Lee WA, et al. Antimicrob Agents Chemother. 2005, 49(5), 1898-1906. 3. Murakami E, et al. Antimicrob Agents Chemother. 2015, 59(6), 3563-3569. 4. Fical L. Vývoj UHPLC-MS/MS metody pro analýzu vybraných antivirotik v HILIC a RP módu[J]. 2020 5. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.

TargetMolCitations

1. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes. Molecules. 2021, 26(8): 2123.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Approved Drug Library FDA-Approved Drug Library Immunology/Inflammation Compound Library Clinical Compound Library Pediatric Drug Library Anti-Infection Compound Library Inhibitor Library NO PAINS Compound Library Drug Repurposing Compound Library

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Keywords

Tenofovir alafenamide 379270-37-8 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase Human immunodeficiency virus GS7340 Inhibitor inhibit HIV GS-7340 GS 7340 inhibitor

 

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