Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 35.00 | |
2 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 81.00 | |
10 mg | In stock | $ 123.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 548.00 | |
500 mg | In stock | $ 1,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. |
In vitro | Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL. The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p < 0.0001). Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced. TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And cyclophilin A after 6 h of activation inhibited by TMN 355(1 μM). |
Molecular Weight | 380.8 |
Formula | C21H14ClFN2O2 |
CAS No. | 1186372-20-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (82.06 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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TMN355 1186372-20-2 Others Inhibitor inhibit TMN-355 TMN 355 inhibitor