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Suberosin

Catalog No. T5795 CAS 581-31-7

Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mosquito larvicidal agent.

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Suberosin, CAS 581-31-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 115.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 279.00
100 mg	In stock	$ 413.00
1 mL * 10 mM (in DMSO)	In stock	$ 90.00

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Purity: 99.12%

Purity: 97.08%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mosquito larvicidal agent.
In vitro	Suberosin suppressed PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase. Suberosin suppressed, in activated PBMC, transcripts of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and cyclins D3, E, A, and B. DNA binding activity and nuclear translocation of NF-AT and NF-kappaB induced by PHA were blocked by suberosin. Suberosin decreased the rise in intracellular Ca2+ concentration ([Ca2+]i) in PBMC stimulated with PHA. Suberosin did not affect phosphorylation of p38 and JNK but did reduce activation of ERK in PHA-treated PBMC. Pharmacological inhibitors of NF-kappaB, NF-AT, and ERK decreased expression of mRNA for the cyclins, IL-2, and IFN-gamma and cell proliferation in PBMC activated by PHA.
Cell Research	Proliferation of PBMC in culture was measured by uptake of 3H-thymidine; production of cytokines and cyclins by Western blotting and RT-PCR. Transcription factors NF-AT and NF-kappaB were assayed by immunocytochemistry and EMSA
Source	Natural Products > Apiaceae > Angelica

Molecular Weight	244.29
Formula	C15H16O3
CAS No.	581-31-7

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (184.21 mM)

References and Literature

1. Chen Y C , Tsai W J , Wu M H , et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-B [J]. British Journal of Pharmacology, 2007, 150(3):298-312.

Related compound libraries

This product is contained In the following compound libraries：

Oxidation-Reduction Compound Library Anti-Cancer Compound Library Human Metabolite Library Transcription Factor-Targeted Compound Library Anti-Aging Compound Library Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library Anti-Prostate Cancer Compound Library Food as Medicine Compound Library PBCRBS Traditional Chinese Medicine Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Suberosin 581-31-7 NF-Κb Others NF-κB Nuclear factor-κB Inhibitor Nuclear factor-kappaB inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.