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Sinensetin

Catalog No. T4S0227 CAS 2306-27-6

Synonyms: Pedalitin permethyl ether

Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.

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Sinensetin, CAS 2306-27-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 57.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 282.00
100 mg	In stock	$ 418.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 98.93%

Purity: 98.68%

Purity: 97.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
In vitro	Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).
In vivo	Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish.
Source	Natural Products > Rutaceae > Citrus

Synonyms	Pedalitin permethyl ether
Molecular Weight	372.37
Formula	C20H20O7
CAS No.	2306-27-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.72 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8. 2. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9. 3. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56.

Related compound libraries

This product is contained In the following compound libraries：

Tobacco Monomer Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Aging Compound Library Immuno-Oncology Compound Library Traditional Chinese Medicine Monomer Library RO5 Drug-like Natural Product Library Anti-Fibrosis Compound Library Flavonoid Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Human Metabolite Library

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Keywords

Sinensetin 2306-27-6 Apoptosis Immunology/Inflammation TNF PGE Synthase inhibit Tumor Necrosis Factor Receptor Pedalitin permethyl ether Inhibitor TNF Receptor TNFR Prostaglandin E synthase PGE synthase inhibitor

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