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Silibinin

Catalog No. T1660 CAS 22888-70-6

Synonyms: Silibinin A, Silybin, Silymarin I

Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.

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Silibinin, CAS 22888-70-6

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.76%

Purity: 98.35%

Purity: 98.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
In vivo	Research indicates that silibinin protects liver cells from toxin-induced damage, serving a hepatoprotective function. In vitro, studies demonstrate that silibinin exhibits anticancer effects against a variety of human cancer cells, including prostate cancer cells, estrogen-dependent/independent breast cancer cells, colorectal cancer cells, cervical cancer cells, and both small and non-small cell lung cancer cells. Silibinin is a mixture of the diastereoisomers silibinin A and silibinin B, approximately in a 1:1 ratio.
Source	Natural Products > Asteraceae > Silybum

Synonyms	Silibinin A, Silybin, Silymarin I
Molecular Weight	482.44
Formula	C25H22O10
CAS No.	22888-70-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL, Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Al-Anati L, et al. Mol Nutr Food Res, 2009, 53(4), 460-466. 2. Bhatia N, et al. Cancer Lett, 1999, 147(1-2), 77-84. 3. Hogan FS, et al. J Surg Res 2007, 143(1), 58-65. 4. Sharma G, et al. Anticancer Res, 2003, 23(3B), 2649-2655.

Citations

1. Duan W, Ou Z, Huang Y, et al.Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries.Antioxidants.2023, 12(12): 2119.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Antioxidant Compound Library ReFRAME Related Library Cuproptosis Compound Library Polyphenolic Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Silibinin 22888-70-6 Autophagy Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibit Silibinin A Inhibitor Silybin Silymarin I inhibitor

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