Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SHIN1 (RZ-2994) is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 312.00 | |
10 mg | In stock | $ 528.00 | |
25 mg | In stock | $ 859.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,580.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 273.00 |
Description | SHIN1 (RZ-2994) is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM. |
Targets&IC50 | SHMT1:5 nM, SHMT2:13 nM |
In vitro | SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50: 10 nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates [1]. |
Synonyms | RZ-2994 |
Molecular Weight | 400.47 |
Formula | C24H24N4O2 |
CAS No. | 2146095-85-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (124.85 mM)
You can also refer to dose conversion for different animals. More
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SHIN1 2146095-85-2 Others RZ 2994 SHIN 1 Inhibitor RZ-2994 SHIN-1 inhibit RZ2994 inhibitor