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L-161982

Catalog No. T15681 CAS 147776-06-5

L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.

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L-161982, CAS 147776-06-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 322.00
25 mg	In stock	$ 572.00
50 mg	In stock	$ 815.00
100 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 99.91%

Purity: 99.44%

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Description	L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.
In vitro	In squamous carcinoma Tca8113 cells, L-161982 induces apoptosis and cell cycle arrest, and inhibits prostaglandin E2-induced proliferation [2]. L-161982 (10 μM) blocks PGE2-stimulated cell proliferation of HCA-7 cells and ERK phosphorylation[3].
In vivo	In collagen-induced arthritis (CIA) mice model, L-161982 (5 mg/kg; i.p.) reduces arthritis lesions and lesion progression. L-161982 shows less joint swelling and lower arthritis score after 35 days post immunization[1].

Molecular Weight	654.72
Formula	C32H29F3N4O4S2
CAS No.	147776-06-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (13.75 mM)

References and Literature

1. Cherukuri DP, et al. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.Exp Cell Res. 2007 Aug 15;313(14):2969-79. 2. Chen L, et al. L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.BMC Musculoskelet Disord. 2017 Nov 16;18(1):462. 3. Li X, et al.The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.J Oral Pathol Med. 2017 Nov;46(10):991-997.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

L-161982 147776-06-5 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor colon cancer L 161982 phosphorylation prostaglandin arthritis inhibit proliferation Inhibitor L161982 inhibitor

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