Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 155.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 589.00 | |
25 mg | In stock | $ 945.00 | |
50 mg | In stock | $ 1,280.00 | |
100 mg | In stock | $ 1,730.00 | |
500 mg | In stock | $ 3,460.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 456.00 |
Description | SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. |
In vivo | SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes.??SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4).?Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation. |
Molecular Weight | 483.54 |
Formula | C24H25N3O6S |
CAS No. | 781628-99-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (134.43 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SBI-477 781628-99-7 Others SBI477 Inhibitor inhibit SBI 477 inhibitor