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SB-277011

Catalog No. T12861   CAS 215803-78-4
Synonyms: SB-277011A

SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively.

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SB-277011 Chemical Structure
SB-277011, CAS 215803-78-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 68.00
5 mg In stock $ 89.00
10 mg In stock $ 142.00
25 mg In stock $ 267.00
50 mg In stock $ 445.00
100 mg In stock $ 656.00
1 mL * 10 mM (in DMSO) In stock $ 93.00
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Purity: 98.61%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively.
Targets&IC50 D3 receptor:8.0 (pKi), 5-HT1B:<5.2 (pKi), 5-HT1D:5.0 (pKi), D2 receptor:6.0 (pKi)
Synonyms SB-277011A
Molecular Weight 438.56
Formula C28H30N4O
CAS No. 215803-78-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.39 mg/mL (10 mM)

TargetMolReferences and Literature

1. Clément P, Pozzato C, Heidbreder C, Alexandre L, Giuliano F, Melotto S.Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat.J Sex Med. 2009 Apr;6(4):980-8. Epub 2008 Feb 4. 2. Gyertyán I, Sághy K.The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats.Eur J Pharmacol. 2007 Oct 31;572(2-3):171-Epub 2007 Jun 29. 3. Southam E, Lloyd A, Jennings CA, Cluderay JE, Cilia J, Gartlon JE, Jones DN.Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain.Brain Res. 2007 May 29;1149:50-7. Epub 2007 Feb 28. 4. Pak AC, Ashby CR Jr, Heidbreder CA, Pilla M, Gilbert J, Xi ZX, Gardner EL.The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.Int J Neuropsychopharmacol. 2006 Oct; 5. Higley, Amanda E.; Kiefer, Stephen W.; Li, Xia; Gaal, Jozsef; Xi, Zheng-Xiong; Gardner, Eliot L. Dopamine D3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. Eur

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Bioactive Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library

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Keywords

SB-277011 215803-78-4 GPCR/G Protein Neuroscience Dopamine Receptor SB-277011A SB 277011 SB277011 inhibitor inhibit

 

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