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Riociguat

Catalog No. T6968 CAS 625115-55-1

Synonyms: BAY 632521

Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.

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Riociguat, CAS 625115-55-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 60.00
10 mg	In stock	$ 96.00
25 mg	In stock	$ 166.00
50 mg	In stock	$ 252.00
100 mg	In stock	$ 432.00
500 mg	In stock	$ 982.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.95%

Purity: 99.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
In vitro	BAY 63-2521 (Riociguat) concentration-dependently stimulates the recombinant soluble guanylate cyclase (sGC) from 0.1 to 100 μM, resulting in a two-fold to 73-fold increase, through an NO-independent but haem-dependent mechanism. [1] Additionally, Riociguat impairs platelet function in isolated platelets, though it does not affect platelets in whole blood, nor does it directly influence the contractility and relaxation of cardiac myocytes. [2] [3]
In vivo	In a long-term study, Riociguat (10 mg/kg/d, orally) was found to partially mitigate pulmonary arterial hypertension, right heart hypertrophy, and structural remodeling of lung vasculature in hypoxic mice and monocrotaline (MCT)-injected rats. [1]

Synonyms	BAY 632521
Molecular Weight	422.42
Formula	C20H19FN8O2
CAS No.	625115-55-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 78 mg/mL (184.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Schermuly RT, et al. Eur Respir J. 2008, 32(4), 881-891. 2. Reiss C, et al. Br J Pharmacol. 2015, 172(21), 5199-5210. 3. Reinke Y, et al. Eur J Pharmacol. 2015, 767, 1-9.

Citations

1. Liu R, Kang Y, Chen L. Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nature Communications. 2021, 12(1): 1-10.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Pediatric Drug Library Anti-Fibrosis Compound Library Anti-Cancer Compound Library Anti-Hypertension Compound Library

Related Products

Related compounds with same targets

Olinciguat Nitroprusside disodium dihydrate Glutaminyl Cyclase Inhibitor 1 NS-2028 BAY 41-8543 Ataciguat MCUF-651 Uroguanylin (human)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Riociguat 625115-55-1 GPCR/G Protein Guanylate cyclase Inhibitor BAY-632521 inhibit Guanylate Cyclase BAY632521 BAY 632521 inhibitor

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