Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 47.00 | |
50 mg | In stock | $ 63.00 | |
100 mg | In stock | $ 108.00 | |
200 mg | In stock | $ 162.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections. |
In vitro | Rifapentine inhibits the function of DNA-dependent RNA polymerase in strains of M. tuberculosis, while inducing no effect on mammalian cells. Both Rifapentine and its active metabolite, 25-desacetylrifapentine, localize within monocyte-derived macrophages, thus allowing for intracellular inhibition of M. tuberculosis at a greater kill rate as compared with that of the parent or metabolite alone. Rifapentine is deacetylated in the liver and induces cytochrome P450 much less than rifampin. [1] Rifapentine has shown higher bacteriostatic and bactericidal activities (MICs and MBCs) than RMP, especially against intracellular bacteria growing in human monocyte-derived macrophages. [2] |
In vivo | Rifapentine inhibits bacterial RNA synthesis by binding to the β-subunit of DNA-dependent RNA polymerase in susceptible species. Rifapentine is generally more active than rifampicin against sensitive strains of M. tuberculosis. [3] Rifapentine significantly increases the rate of antipyrine and pentobarbital metabolism in vivo. Rifapentine also increases liver weight, the content of liver microsomal protein and cytochrome P-450, the activity of NADPH-cytochrome C reductase and NADPH oxidase. [4] Rifapentine combined with isoniazid (INH) and pyrazinamide (PZA) administered daily results in an apparent clearance of M.tuberculosis organisms in the lungs and spleens of infected mice after 10 weeks of treatment. [5] |
Synonyms | MDL473, Rifapentina, Rifapentinum, DL 473, Priftin, Cyclopentylrifampicin |
Molecular Weight | 877.03 |
Formula | C47H64N4O12 |
CAS No. | 61379-65-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 93 mg/mL (106 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 14 mg/mL (16 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rifapentine 61379-65-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis Antibacterial Antibiotic MDL473 inhibit DL473 Bacterial Rifapentina Inhibitor MDL 473 Rifapentinum DL 473 MDL-473 DL-473 Priftin Cyclopentylrifampicin inhibitor