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RAD51 Inhibitor B02
🥰Excellent
Catalog No. T4656Cas No. 1290541-46-6
Alias B02
RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
RAD51 Inhibitor B02
🥰Excellent
Purity: 99.89%
Catalog No. T4656Alias B02Cas No. 1290541-46-6
RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $42 | In Stock | In Stock | |
| 10 mg | $72 | In Stock | In Stock | |
| 25 mg | $153 | In Stock | In Stock | |
| 50 mg | $248 | In Stock | In Stock | |
| 100 mg | $398 | In Stock | In Stock | |
| 200 mg | $583 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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Product Introduction
Bioactivity
Chemical Properties
| Description | RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. |
| Targets&IC50 | RAD51:27.4 μM |
| In vitro | RAD51 Inhibitor B02 selectively inhibits human RAD51 (IC50 = 27.4 μM) without affecting its E. coli homologue RecA (IC50 > 250 μM). Combining B02 with cisplatin exhibits a potent cytotoxic effect on human breast cancer cells [MDA-MB-231].' |
| In vivo | B02 substantially improves the therapeutic efficacy of cisplatin against tumor cells in vivo, demonstrating tolerability in mice at dosages up to 50 mg/kg without significant body weight reduction. Mice treated solely with B02 exhibited no tumor growth inhibition; however, those administered 4 mg/kg of cisplatin experienced a 33% reduction in tumor growth. Crucially, a combination treatment involving 50 mg/kg B02 and 4 mg/kg cisplatin resulted in a 66% decrease in tumor size[2]. |
| Synonyms | B02 |
| Molecular Weight | 339.39 |
| Formula | C22H17N3O |
| Cas No. | 1290541-46-6 |
| Smiles | O=c1n(Cc2ccccc2)c(\C=C\c2cccnc2)nc2ccccc12 |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33.9 mg/mL (99.89 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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