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RAD51 Inhibitor B02

Catalog No. T4656 CAS 1290541-46-6

Synonyms: B02

RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.

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RAD51 Inhibitor B02, CAS 1290541-46-6

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 170.00
50 mg	In stock	$ 277.00
100 mg	In stock	$ 457.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 99.9%

Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
Targets&IC50	RAD51:27.4 μM
In vitro	RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM).The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231.
In vivo	B02 substantially improves the therapeutic efficacy of cisplatin against tumor cells in vivo, demonstrating tolerability in mice at dosages up to 50 mg/kg without significant body weight reduction. Mice treated solely with B02 exhibited no tumor growth inhibition; however, those administered 4 mg/kg of cisplatin experienced a 33% reduction in tumor growth. Crucially, a combination treatment involving 50 mg/kg B02 and 4 mg/kg cisplatin resulted in a 66% decrease in tumor size[2].

Synonyms	B02
Molecular Weight	339.39
Formula	C22H17N3O
CAS No.	1290541-46-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.9 mg/mL(100 mM)

References and Literature

1. Huang F, et al. Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem Biol. 2011 Jun 17;6(6):628-35. 2. Huang F, et al. A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts. PLoS One. 2014 Jun 27;9(6):e100993.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Aging Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library Cell Cycle Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RAD51 Inhibitor B02 1290541-46-6 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis B 02 RAD-51 Inhibitor B02 RAD51 Inhibitor B-02 inhibit B02 inhibitor

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