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Pyridostatin Trihydrochloride

Catalog No. T4457 CAS T4457

Synonyms: Pyridostatin Trihydrochloride(free base 1085412-37-8 ), RR-82 Trihydrochloride

Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pyridostatin Trihydrochloride Chemical Structure

Pyridostatin Trihydrochloride, CAS T4457

Pack Size	Availability	Price/USD
1 mg	In stock	$ 35.00
2 mg	In stock	$ 47.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 201.00
50 mg	In stock	$ 305.00
100 mg	In stock	$ 513.00

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Purity: 96.98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.
Targets&IC50	G-quadruplexe:Kd:490 nM
In vitro	Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes
Cell Research	Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments.

Synonyms	Pyridostatin Trihydrochloride(free base 1085412-37-8 ), RR-82 Trihydrochloride
Molecular Weight	706.02
Formula	C31H35Cl3N8O5
CAS No.	T4457

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (70.82 mM)

H2O: 7.09 mg/mL(10 mM）, Sonification is recommended.

References and Literature

1. Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7. 2. Moruno-Manchon JF,etal.The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.Aging (Albany NY). 2017 Sep 12;9(9):1957-1970. 3. Rodriguez R,etal.Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.Nat Chem Biol. 2012 Feb 5;8(3):301-10.

Citations

1. Li C, Yin Z, Xiao R, et al.G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.Genome Biology.2022, 23(1): 1-29. 2. Wang J, Huang H, Zhao K, et al.G-quadruplex in Hepatitis B Virus pregenomic RNA Promotes its Translation.Journal of Biological Chemistry.2023: 105151. 3. Zhang Y, Cheng Y, Luo Q, et al.Distinguishing G-Quadruplexes Stabilizer and Chaperone for c-MYC Promoter G-Quadruplexes through Single-Molecule Manipulation.Journal of the American Chemical Society.2024

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Cell Cycle Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Pyridostatin Trihydrochloride T4457 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis RR 82 Trihydrochloride RR82 RR 82 Pyridostatin Trihydrochloride(free base 1085412-37-8 ) Pyridostatin RR-82 Trihydrochloride RR82 Trihydrochloride RR-82 inhibitor inhibit

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