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Pregnenolone monosulfate

Catalog No. T12536   CAS 1247-64-9
Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in studies of neuroticism and depression.

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Pregnenolone monosulfate Chemical Structure
Pregnenolone monosulfate, CAS 1247-64-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 46.00
10 mg In stock $ 64.00
25 mg In stock $ 126.00
1 mL * 10 mM (in DMSO) In stock $ 53.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in studies of neuroticism and depression.
In vitro Pregnenolone monosulfate, as a signaling-specific negative allosteric modulator, antagonizes most of the known behavioral and in vivo effects of THC. The effect of THC is significantly attenuated when slices are pre-treated with 100 nM Pregnenolone monosulfate (inhibition rate of 15.1±1.8%).
Synonyms 3β-Hydroxy-5-pregnen-20-one monosulfate
Molecular Weight 396.54
Formula C21H32O5S
CAS No. 1247-64-9

Storage

store at low temperature,store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (126.09 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. 2. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. 3. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7.

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Keywords

Pregnenolone monosulfate 1247-64-9 Neuroscience NMDAR 3β-Hydroxy-5-pregnen-20-one 3b-Hydroxy-5-pregnen-20-one Monosulfate 3beta-Hydroxy-5-pregnen-20-one Monosulfate 3beta-Hydroxy-5-pregnen-20-one 3β-Hydroxy-5-pregnen-20-one monosulfate Pregnenolone 3b-Hydroxy-5-pregnen-20-one inhibitor inhibit

 

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