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Ro 8-4304

Catalog No. T8447 CAS 195988-65-9

Synonyms: Ro 8-4304 Hydrochloride

Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM

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Ro 8-4304, CAS 195988-65-9

Pack Size	Availability	Price/USD
1 mg	8-10 weeks	$ 134.00
5 mg	8-10 weeks	$ 302.00
10 mg	8-10 weeks	$ 453.00
25 mg	8-10 weeks	$ 681.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
Targets&IC50	NMDA:0.4 μM
In vitro	Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.?The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively.?Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors

Synonyms	Ro 8-4304 Hydrochloride
Molecular Weight	370.424
Formula	C21H23FN2O3
CAS No.	195988-65-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kew J N C , Trube G , Kemp J A . State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist[J]. British Journal of Pharmacology, 1998, 123(3):463-472. 2. Huang S , Balgi A , Pan Y , et al. Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics[J]. 2016, 009(012):1620-1633.

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Keywords

Ro 8-4304 195988-65-9 Neuroscience NMDAR Ro 84304 Ro 8 4304 Ro 8-4304 Hydrochloride Inhibitor inhibitor inhibit

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