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Pentaethylene glycol di(p-toluenesulfonate)

Catalog No. T18537 CAS 41024-91-3

Synonyms: Penta(ethylene glycol) bis(p-toluenesulfonate), Bis-Tos-PEG5

Pentaethylene glycol di(p-toluenesulfonate) (Penta(ethylene glycol) bis(p-toluenesulfonate)) is a PEG-based PROTAC linker. Pentaethylene glycol di(p-toluenesulfonate) can be used in the synthesis of PROTACs.

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Pentaethylene glycol di(p-toluenesulfonate) Chemical Structure

Pentaethylene glycol di(p-toluenesulfonate), CAS 41024-91-3

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Purity: 99.44%

Biological Description

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Storage & Solubility Information

Description	Pentaethylene glycol di(p-toluenesulfonate) (Penta(ethylene glycol) bis(p-toluenesulfonate)) is a PEG-based PROTAC linker. Pentaethylene glycol di(p-toluenesulfonate) can be used in the synthesis of PROTACs.
In vitro	PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Synonyms	Penta(ethylene glycol) bis(p-toluenesulfonate), Bis-Tos-PEG5
Molecular Weight	546.65
Formula	C24H34O10S2
CAS No.	41024-91-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Related Products

Related compounds with same targets

Biotin-EDA N-Boc-PEG5-bromide NH2-C2-NH-Boc Fmoc-NH-PEG10-acid Amino-PEG13-amine Bis-Tos-PEG4 Boc-NH-PEG11-NH2 Boc-NH-PEG11-OH

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pentaethylene glycol di(p-toluenesulfonate) 41024-91-3 Others PROTAC PROTAC Linker Pentaethylene glycol di(ptoluenesulfonate) Penta(ethylene glycol) bis(p-toluenesulfonate) Pentaethylene glycol di(p toluenesulfonate) Inhibitor Bis-Tos-PEG5 PROTAC Linkers inhibit inhibitor

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