Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 159.00 | |
5 mg | In stock | $ 398.00 | |
10 mg | In stock | $ 592.00 | |
25 mg | In stock | $ 947.00 | |
50 mg | In stock | $ 1,280.00 | |
100 mg | In stock | $ 1,730.00 |
Description | PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects. |
In vitro | In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold[2]. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors[4]. |
In vivo | PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes[3]. |
Synonyms | PSB 603 |
Molecular Weight | 529.01 |
Formula | C24H25ClN6O4S |
CAS No. | 1092351-10-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 23.9mg/mL (45.1mM)
You can also refer to dose conversion for different animals. More
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PSB-603 1092351-10-4 GPCR/G Protein Neuroscience Adenosine Receptor PSB603 PSB 603 inhibitor inhibit