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PROCYANIDIN C1
🥰Excellent
Catalog No. TN2103Cas No. 37064-30-5
Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells.
PROCYANIDIN C1
🥰Excellent
Purity: 99.86%
Catalog No. TN2103Cas No. 37064-30-5
Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $72 | In Stock | |
| 5 mg | $322 | In Stock | |
| 10 mg | $537 | In Stock | |
| 25 mg | $857 | In Stock | |
| 50 mg | $1,150 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $513 | In Stock |
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Purity:99.86%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells. |
| In vitro | METHODS: PSC27 cells were treated with Procyanidin C1 (5, 10, 25, 50, 100, 400 μM) and senescent PSC27 cell survival was measured by SA-β-Gal staining. RESULTS Procyanidin C1 exerted an anti-senescent effect on senescent stromal cells starting at a concentration of 50 μM, at which concentration proliferating cells were largely unaffected. [1] METHODS: Procyanidin C1 (5 and 10 μM) was used in DLD1 and HCT116 cells, and the expression of has-miR-501-3p was detected. RESULTS Procyanidin C1 inhibited the expression of has-miR-501-3p in CRC cells with increasing concentrations. [4] |
| In vivo | METHODS: DLD1 and SW1463 cells were injected into the right axilla of BALB/c nude mice. The nude mice were treated with Procyanidin C1 (20 mg/kg and 40 mg/kg, intraperitoneal injection, once every three days), and the tumor volume and tumor weight were calculated. METHODS: Procyanidin C1 can inhibit tumor growth and metastasis in CRC, and the has-miR-501-3p/HIGD1A axis is involved in this process. [4] |
| Molecular Weight | 866.77 |
| Formula | C45H38O18 |
| Cas No. | 37064-30-5 |
| Smiles | O[C@@H]1Cc2c(O)cc(O)c([C@@H]3[C@@H](O)[C@H](Oc4c([C@@H]5[C@@H](O)[C@H](Oc6cc(O)cc(O)c56)c5ccc(O)c(O)c5)c(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1 |
| Relative Density. | 1.747g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (34.61 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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