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PROCYANIDIN C1

Name: PROCYANIDIN C1
Brand: TargetMol
SKU: TN2103
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2103Cas No. 37064-30-5

Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells.

PROCYANIDIN C1

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Purity: 99.86%

Catalog No. TN2103Cas No. 37064-30-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$72	In Stock	In Stock
5 mg	$322	In Stock	In Stock
10 mg	$496	In Stock	In Stock
25 mg	$845	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$513	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

PROCYANIDIN C1 AI Summary

PROCYANIDIN C1 is a bioactive molecule with multifaceted pharmacological properties. It exhibits anti-HIV activity in cell culture, with IC50 and EC50 values exceeding 25000 nM, and inhibits HIV replication and reverse transcriptase at 20 ug/mL, demonstrating 68.0% and 18.0% inhibition, respectively. The compound also inhibits protein kinase C with an IC50 of 40000 nM and competitively displaces phorbol [3H]PDBu at concentrations of 50 uM or less. It shows cytotoxic effects on multiple human cell lines, including TE671, HCT8, A549, KB, and PRMI7951, with an ED50 greater than 10.0 ug/mL. In addition, PROCYANIDIN C1 has broad-spectrum antimicrobial activity, targeting bacterial strains such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, with MIC and MBC values over 100.0 ug/mL. It also shows antiviral activity in HIV-infected human MT4 cells with an IC50 of 4.3 ug/mL and a cytotoxicity CC50 of 16.5 ug/mL. The compound modulates the alternative complement pathway with an IC50 of 85500 nM and the classical complement pathway with an IC50 of 6000 nM. Moreover, PROCYANIDIN C1 demonstrates significant antioxidant activities, including scavenging superoxide radicals, ABTS radicals (8.29 MU), and DPPH radicals (8.79 MU and IC50 of 6.2 ug/mL), and inhibits lipid peroxidation in various assays. It also inhibits various metalloproteinases such as collagenase type 4 and gelatinases A and B from synovial fibroblasts and neutrophils, with IC50 values of 11300 nM, 31400 nM, and 53200 nM, respectively. Additionally, PROCYANIDIN C1 induces H2O2-inactivated bovine milk lactoperoxidase pseudo-halogenating activity, resulting in increased hypothiocyanate formation, with kinetic parameters of Kcat 6.43 /s, Km 8410 nM, and a Kcat/Km ratio of 0.8 /uM/s, suggesting a potential role in redox biology. Overall, PROCYANIDIN C1 shows promise as an antiviral, antimicrobial, antioxidant, and anticancer agent, indicating its potential for therapeutic development across a range of diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells.
In vitro	METHODS: PSC27 cells were treated with Procyanidin C1 (5, 10, 25, 50, 100, 400 μM) and senescent PSC27 cell survival was measured by SA-β-Gal staining. RESULTS Procyanidin C1 exerted an anti-senescent effect on senescent stromal cells starting at a concentration of 50 μM, at which concentration proliferating cells were largely unaffected. [1] METHODS: Procyanidin C1 (5 and 10 μM) was used in DLD1 and HCT116 cells, and the expression of has-miR-501-3p was detected. RESULTS Procyanidin C1 inhibited the expression of has-miR-501-3p in CRC cells with increasing concentrations. [4]
In vivo	METHODS: DLD1 and SW1463 cells were injected into the right axilla of BALB/c nude mice. The nude mice were treated with Procyanidin C1 (20 mg/kg and 40 mg/kg, intraperitoneal injection, once every three days), and the tumor volume and tumor weight were calculated. METHODS: Procyanidin C1 can inhibit tumor growth and metastasis in CRC, and the has-miR-501-3p/HIGD1A axis is involved in this process. [4]

Chemical Properties

Molecular Weight	866.77
Formula	C₄₅H₃₈O₁₈
Cas No.	37064-30-5
Smiles	O[C@@H]1Cc2c(O)cc(O)c([C@@H]3[C@@H](O)[C@H](Oc4c([C@@H]5[C@@H](O)[C@H](Oc6cc(O)cc(O)c56)c5ccc(O)c(O)c5)c(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
Relative Density.	1.747g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.14 mg/mL (104 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1537 mL	5.7685 mL	11.5371 mL	57.6854 mL
5 mM	0.2307 mL	1.1537 mL	2.3074 mL	11.5371 mL
10 mM	0.1154 mL	0.5769 mL	1.1537 mL	5.7685 mL
20 mM	0.0577 mL	0.2884 mL	0.5769 mL	2.8843 mL
50 mM	0.0231 mL	0.1154 mL	0.2307 mL	1.1537 mL
100 mM	0.0115 mL	0.0577 mL	0.1154 mL	0.5769 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc