Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 213.00 | |
100 mg | In stock | $ 345.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 60.00 |
Description | PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies. |
In vitro | PQM130 had already shown anti-inflammatory activity in different in vivo models and neuroprotective activity in human neuronal cells. |
In vivo | The intracerebroventricular (i.c.v.) injection of AβO in mice caused the increase of memory impairment, oxidative stress, neurodegeneration, and neuroinflammation.?Instead, PQM130 (0.5-1 mg/kg) treatment after the i.c.v. AβO injection reduced oxidative damage and neuroinflammation and induced cell survival and protein synthesis through the modulation of glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinases (ERK1/2).?Moreover, PQM130 increased brain plasticity and protected mice against the decline in spatial cognition.?PQM130 modulated different pathways compared to donepezil, and it is much more effective in counteracting AβO damage. |
Molecular Weight | 381.46 |
Formula | C23H27NO4 |
CAS No. | 2089415-51-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.5 mg/mL (14.42 mM)
You can also refer to dose conversion for different animals. More
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PQM130 2089415-51-8 Neuroscience Beta Amyloid Inhibitor Amyloid-β β-amyloid peptide Abeta PQM 130 PQM-130 inhibit inhibitor