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Catalog No. T2616   CAS 593960-11-3
Synonyms: PIK 93, PIK93

PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.

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PIK-93, CAS 593960-11-3
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Targets&IC50 PI3Kα:39 nM, PI4K:19 nM
Kinase Assay Assay of PI3Ks: IC50 values are measured using a standard TLC assay for lipid kinase activity. Kinase reactions are performed by preparing areaction mixture containing kinase, PIK-93 (2% DMSO final concentration), buffer (25 mM HEPES, pH 7.4, 10 mM MgCl2), and freshly sonicated phosphatidylinositol (100 μg/ml). Reactions are initiated by the addition of ATP containing 10 μCi of γ-32P-ATP to a final concentration 10 or 100 μM, and allowed to proceed for 20 min at room temperature. For TLC analysis, reactions are then terminated by the addition of 105 μL 1N HCl followed by 160 μL CHCl3:MeOH (1:1). The biphasic mixture is vortexed, briefly centrifuged, and the organic phase transferred to a new tube using a gel loading pipette tip precoated with CHCl3. This extract is spotted on TLC plates and developed for 3 hours–4 hours in a 65:35 solution of n-propanol:1M acetic acid. The TLC plates are then dried, exposed to a phosphorimager screen, and quantitated. Kinase activity is typically measured at 10–12 concentrations of PIK-93 representing two-fold dilutions from the highest concentration of 100 μM.
Cell Research For actin staining, dHL60 cells are preincubated in suspension with PIK-93 or vehicle for 40 min, centrifuged for 5 min at 2000 rpm at room temperature in a J6-B centrifuge, resuspended in mHBSS containing the respective agent at the same concentration, allowed to stick to fibronectin-covered coverslips, and subjected to stimulation with a uniform concentration of 100 nM f-Met-Leu-Phe (fMLP) for 3 min. Cellsare fixed in 3.7% PFA and stained with 10 units/mL rhodamine-phalloidin for 15 min.(Only for Reference)
Synonyms PIK 93, PIK93
Molecular Weight 389.87
Formula C14H16ClN3O4S2
CAS No. 593960-11-3


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 39 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Knight ZA, Cell, 2006, 125(4), 733-747. 2. VanKeymeulen A, et al. Cell Biol. 2006, 174(3), 437-445. 3. Tóth B, et al. J BiolChem, 2006, 281(47), 36369-3637 4. Monet M, et al. J BiolChem, 2012, Epub ahead of print. 5. Arita M, et al. J Virol, 2011, 85(5), 2364-2372.

Related compound libraries

This product is contained In the following compound libraries:
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PIK-93 593960-11-3 DNA损伤和修复 PI3K/Akt/mTOR信号通路 代谢 微生物学 ATM/ATR Carbonic Anhydrase DNA-PK HSV mTOR PI3K PI4K Virus Protease Phosphatidylinositol 4 kinases PI4 kinases Phosphoinositide 3-kinase inhibit PIK 93 Inhibitor PIK93 inhibitor