Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 122.00 | |
5 mg | In stock | $ 278.00 | |
10 mg | In stock | $ 447.00 | |
25 mg | In stock | $ 739.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,390.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 293.00 |
Description | PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM). |
Targets&IC50 | PI3Kγ:20 μM, PI4KIIIα:3 μM, PI4KIIIβ:3.6 nM, PI3Kα:10 μM, PI3KC2γ:1 μM, PI3Kδ:720 nM |
In vitro | The most potent of these molecules (PI4KIIIbeta-IN-10;compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested. Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ[1]. |
Molecular Weight | 475.58 |
Formula | C22H25N3O5S2 |
CAS No. | 1881233-39-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (63.08 mM)
You can also refer to dose conversion for different animals. More
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PI4KIIIbeta-IN-10 1881233-39-1 PI3K/Akt/mTOR signaling PI4K PI3K inhibit Phosphatidylinositol 4 kinases Inhibitor PI4 kinases PI4KIIIβ-IN-10 PI4KIIIbetaIN10 PI-4KIIIbeta-IN-10 PI4KIIIb-IN-10 PI4KIIIbeta IN 10 inhibitor