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Cytoskeletal Signaling Akt PHT427

PHT427

Catalog No. T2420   CAS 1191951-57-1
Synonyms: PHT 427, PHT-427, CS-0223

PHT-427 is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).

PHT427, CAS 1191951-57-1
Pack Size Availability Price/USD Quantity
5 mg In stock 38.00
10 mg In stock 54.00
25 mg In stock 114.00
50 mg In Stock 212.00
100 mg In Stock 381.00
200 mg In Stock 687.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.77%
Purity 100.00%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
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Description PHT-427 is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
Targets&IC50 Akt ,   PDK1
Kinase Assay Surface plasmon resonance (SPR) spectroscopy binding assays: All interaction analyses are performed with a Biacore 2000, Biacore 2000 Control Software v3.2, and BIAevaluation v4.1 analysis software. The PH domain GST-fusion proteins (Akt1, IRS1, and PDK1) are immobilized on a CM5 Sensorchip using Biacore's Amine Coupling Kit to a level of 10,000 Response units (RUs). Small molecule analytes at concentrations ranging from 0.1 to 10 × the predicted KD are injected at a high flow rate (30μL/min). DMSO concentrations in all samples and running buffer are 1% (v/v) or less.
Synonyms PHT 427 , PHT-427 , CS-0223
Purity 99.77%
Molecular Weight 409.61
Formula C20H31N3O2S2
CAS No. 1191951-57-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 41 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

5% DMSO+95% Corn oil: 5 mg/mL

Citations

References and Literature
1. Meuillet EJ, et al. Mol Cancer Ther, 2010, 9(3), 706-717. 2. Moses SA, et al. Cancer Res, 2009, 69(12), 5073-5081.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Stem cell Differentiation Compound Library Apoptosis Compound Library Autophagy Compound Library PI3K-AKT-mTOR Compound Library Kinase Inhibitor Library Anti-cancer Metabolism Compound Library Preclinical Compound Library Promoting Cancer Cell Differentiation Compound Library Anti-obesity Compound Library Anti-aging Compound Library Anti-cancer Active Compound library HIF-1 Signaling Pathway Compound Library Anti-COVID-19 Compound Library ACE2-Targeted compound library (CADD) Anti-Lung Cancer Compound Library Glycometabolism Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Glutamine Metabolism Compound Library

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