Powder: -20°C for 3 years | In solvent: -80°C for 2 years
PF-02413873 is a competitive antagonist of nonsteroidal Progesterone Receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 422.00 | |
100 mg | In stock | $ 628.00 | |
500 mg | In stock | $ 1,350.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis. |
Targets&IC50 | Progesterone receptor:2.6 nM (Ki) |
In vitro | PF-02413873 induces nuclear translocation only at high concentrations (>3 μM). PF-02413873 shows a derived Ki of 9.7 nM in the T47D native functional assay[3]. |
In vivo | In cynomolgus macaques, PF-02413873 (3 mg/kg; p.o.) exhibits a t1/2 of 4.2 h, a Cmax of 162 ng/mL and CL/F of 41 mL/min/kg. PF-02413873 (2.5 and 10 mg/kg; p.o.) reduces the endometrial thickness of 43 and 56%, respectively[3]. |
Synonyms | PF02413873 |
Molecular Weight | 359.44 |
Formula | C18H21N3O3S |
CAS No. | 936345-35-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 95 mg/mL (264.30 mM), ultrasonic and warming and heat to 60°C
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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PF-02413873 936345-35-6 Others Progesterone Receptor nonsteroidal inhibit PF 2413873 PF02413873 endometrial PF-2413873 nuclear PF 02413873 NR3C3 PF2413873 translocation progesterone Inhibitor inhibitor