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Nystatin A3

Catalog No. T6913 CAS 62997-67-5

Synonyms: Fungicidin, Nystatin

Nystatin A3 (Fungicidin) , which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.

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Nystatin A3, CAS 62997-67-5

Pack Size	Availability	Price/USD
25 mg	Inquiry	$ 50.00
50 mg	Inquiry	$ 65.00
100 mg	Inquiry	$ 118.00
200 mg	Inquiry	$ 214.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nystatin A3 (Fungicidin) , which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
In vitro	Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six?Candida?species. [1] Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/ml) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [3H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment. [2] Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of?endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. [3]
In vivo	Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. [3] Liposomal?Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. [4]

Synonyms	Fungicidin, Nystatin
Molecular Weight	1056.24
Formula	C53H85NO20
CAS No.	62997-67-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 16 mg/mL (15.1 mM)

References and Literature

1. Ellepola AN, et al. Oral Microbiol Immunol. 1999 Dec;14(6):358-63. 2. Haas M, et al. Am J Physiol,1994, 266(5 Pt 1), C1440-1452. 3. Chen Y, et al. Blood,2011, 117(23), 6392-6403. 4. Wallace TL, et al. Antimicrob Agents Chemother,1997, 41(10), 2238-2243.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nystatin A3 62997-67-5 Others Fungal Inhibitor Nystatin A 3 inhibit Antibiotic Nystatin A-3 Fungicidin Nystatin inhibitor

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