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Nicotinamide Riboside Triflate

Catalog No. T33663 CAS 445489-49-6

Synonyms: SRT 647 Triflate, SRT 647, Nicotinamide Riboside, Nicotinamide Ribose, SRT-647, SRT647, SRT647 Triflate, SRT-647 Triflate

Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy.

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Nicotinamide Riboside Triflate Chemical Structure

Nicotinamide Riboside Triflate, CAS 445489-49-6

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Description	Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy.
In vitro	Nicotinamide Riboside Triflate (1-1000 μM; HEK293T cells) exhibits a concentration-dependent increase in intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells.[1] Nicotinamide Riboside Triflate (0.5 nM; 24 h; HEK293T cells) reduces the acetylation status of Ndufa9 and SOD2.[1] Nicotinamide Riboside Triflate enhances NAD levels to reinstate the antiviral poly(ADP-ribose) polymerase (PARP) functions, bolstering innate immunity against coronaviruses (CoVs), a contributing factor to COVID-19.[3]
In vivo	Nicotinamide Riboside Triflate (400 mg/kg/day; p.o.; for 16 weeks; 10-week-old C57Bl/6J mice) results in tissue-specific increases in both plasma and intracellular NAD+ levels.[1]

Synonyms	SRT 647 Triflate, SRT 647, Nicotinamide Riboside, Nicotinamide Ribose, SRT-647, SRT647, SRT647 Triflate, SRT-647 Triflate
Molecular Weight	404.32
Formula	C12H15F3N2O8S
CAS No.	445489-49-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. 2. Gong B, et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol Aging. 2013 Jun;34(6):1581-8. 3. Heer CD, et al. Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity. bioRxiv [Preprint]. 2020 Oct 6:2020.04.17.047480. 4. Kourtzidis IA, Dolopikou CF, Tsiftsis AN, Margaritelis NV, Theodorou AA, Zervos IA, Tsantarliotou MP, Veskoukis AS, Vrabas IS, Paschalis V, Kyparos A, Nikolaidis MG. Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance. Exp Physiol. 2018 Oct;103(10):1357-1366. doi: 10.1113/EP086964. Epub 2018 Aug 28. PubMed PMID: 30007015.

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Keywords

Nicotinamide Riboside Triflate 445489-49-6 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin SRT 647 Triflate SRT 647 Nicotinamide Riboside Nicotinamide Ribose SRT-647 SRT647 SRT647 Triflate SRT-647 Triflate inhibitor inhibit

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