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NSI-189 Phosphate

Catalog No. T21244 CAS 1270138-41-4

Synonyms: NSI189 Phosphate, NSI 189 Phosphate

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.

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NSI-189 Phosphate, CAS 1270138-41-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 192.00
100 mg	In stock	$ 287.00
200 mg	In stock	$ 431.00
1 mL * 10 mM (in DMSO)	In stock	$ 77.00

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Purity: 99.95%

Biological Description

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Description

In vivo

NSI-189 actively stimulated remodeling of the stroke brain.?Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF.?These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke[1].

Synonyms	NSI189 Phosphate, NSI 189 Phosphate
Molecular Weight	464.5
Formula	C22H33N4O5P
CAS No.	1270138-41-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (139.94 mM)

References and Literature

1. Tajiri N , Quach D M , Kaneko Y , et al. NSI‐189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats[J]. Journal of Cellular Physiology, 2017. 2. Karl K Johe, Gary Kay, Santosh Kumar, et al.NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder.Ann Clin Psychiatry. 2020 Aug;32(3):182-196.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Metabolism Disease Compound Library NO PAINS Compound Library Anti-Diabetic Compound Library Preclinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library Antidepressant Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

NSI-189 Phosphate 1270138-41-4 Others NSI189 Phosphate NSI 189 Phosphate inhibitor inhibit

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