Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 85.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 238.00 | |
50 mg | In stock | $ 419.00 | |
100 mg | In stock | $ 597.00 | |
500 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 88.00 |
Description | NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM. |
Targets&IC50 | PI5P4Kγ:1 μM |
In vitro | NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes' on the culture dish. NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks. |
Molecular Weight | 385.41 |
Formula | C20H14F3N3S |
CAS No. | 959551-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (142.71 mM)
You can also refer to dose conversion for different animals. More
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NIH-12848 959551-10-1 PI3K/Akt/mTOR signaling PI3K Inhibitor NIH 12848 NIH12848 inhibit inhibitor