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N-Acetyl-5-hydroxytryptamine

Catalog No. T1354 CAS 1210-83-9

Synonyms: Normelatonin, O-Demethylmelatonin, N-Acetylserotonin

N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase. It can potently activate TrkB receptor.

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N-Acetyl-5-hydroxytryptamine Chemical Structure

N-Acetyl-5-hydroxytryptamine, CAS 1210-83-9

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10 mg	In stock	$ 32.00
25 mg	In stock	$ 48.00
50 mg	In stock	$ 67.00

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Purity: 99.91%

Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase. It can potently activate TrkB receptor.
In vitro	N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner[1].
In vivo	To investigate the potential of N-Acetyl-5-hydroxytryptamine (NAS) to activate TrkB in vivo, researchers utilized TrkB F616A knockin mice, which have been demonstrated to exhibit selective inhibition of TrkB F616A activation by 1NMPP1, a derivative of the kinase inhibitor PP1, resulting in TrkB-null phenotypes. The study aimed to determine if NAS could replicate the effects of BDNF. Cortical neurons from TrkB F616A knockin mice were prepared for this purpose. Supporting previous findings, the study showed that NAS and BDNF-induced TrkB phosphorylation were specifically diminished by 1NMPP1, unlike by K252a, while serotonin or melatonin had no impact. These results suggest that NAS significantly induces tyrosine phosphorylation and activation of both wild-type TrkB and TrkB F616A[1].

Synonyms	Normelatonin, O-Demethylmelatonin, N-Acetylserotonin
Molecular Weight	218.25
Formula	C12H14N2O2
CAS No.	1210-83-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (229.1 mM)

Ethanol: 10 mg/mL

References and Literature

1. Jang SW, et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3876-81. 2. Chattoraj A, et al. Melatonin formation in mammals: in vivo perspectives. Rev Endocr Metab Disord. 2009 Dec;10(4):237-43.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Human Endogenous Metabolite Library NO PAINS Compound Library Drug Metabolite/Impurity Library Anti-Tumor Natural Product Library RO5 Drug-like Natural Product Library Gut Microbial Metabolite Library Target-Focused Phenotypic Screening Library Natural Product Library for HTS

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Related compounds with same targets

Trk-IN-4 PF-06273340 TRK-IN-24 Tepotinib CG 428 Larotrectinib Entrectinib GNF-5837

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Keywords

N-Acetyl-5-hydroxytryptamine 1210-83-9 Metabolism Tyrosine Kinase/Adaptors Trk receptor Endogenous Metabolite Normelatonin Tropomyosin related kinase receptor inhibit Inhibitor Trk Receptor N Acetyl 5 hydroxytryptamine O-Demethylmelatonin N-Acetylserotonin NAcetyl5hydroxytryptamine inhibitor

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