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Moracin C

Catalog No. TN1949 CAS 69120-06-5

Synonyms: 5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇, 桑辛素 C

Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.

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Moracin C, CAS 69120-06-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.

In vitro

In the screening of inhibitors of Staphylococcus aureus enoyl-ACP reductase (FabI), we found that a methanol extract of leaves of Morus alba L. potently inhibited S. aureus FabI as well as growth of S. aureus. The active principles were identified as chalcomoracin and Moracin C by MS and NMR analysis. Chalcomoracin and Moracin C inhibited S. aureus FabI with IC(50) of 5.5 and 83.8 μM, respectively. They also prevented the growth of S. aureus with minimum inhibitory concentration (MIC) of 4 and 32 μg/mL, respectively. Consistent with their inhibition against FabI and bacterial growth, they prevented (14)C]acetate incorporation into fatty acid in S. aureus while didn't affect protein synthesis.

Synonyms	5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇, 桑辛素 C
Molecular Weight	310.34
Formula	C19H18O4
CAS No.	69120-06-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba.Biol Pharm Bull. 2012;35(5):791-5.

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Keywords

Moracin C 69120-06-5 免疫与炎症神经科学 NOS COX ROS Inhibitor inhibitor inhibit

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