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Moracin C

Catalog No. TN1949 CAS 69120-06-5

Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells.

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Moracin C, CAS 69120-06-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 198.00
5 mg	In stock	$ 513.00
10 mg	In stock	$ 747.00
25 mg	In stock	$ 1,160.00
50 mg	In stock	$ 1,560.00
100 mg	In stock	$ 2,080.00

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Purity: 99.86%

Purity: 99.32%

Biological Description

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Storage & Solubility Information

Description	Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells.
Targets&IC50	inhibited S. aureus FabI:83.8 µM, prevented the growth of S. aureus:32 µg/mL(MIC)
In vitro	Moracin C (1-50 μM, 24 h) inhibited the release of LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) from RAW264.7 cells.[2] Moracin C (1-50 μM, 2 h) inhibits mRNA and protein expression of iNOS and COX-2 in RAW264.7 cells.[2] Moracin C (1-50 μM, 2 h) inhibits the production of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) in LPS-activated RAW 264.7 cells [1]. Moracin C (1-50 μM, 2 h) inhibits the phosphorylation of p38, ERK and JNK in LPS-activated RAW 264.7 cells.[2]
In vivo	Moracin C (100 mg/kg, gavage, mice) is rapidly and well absorbed in the intestinal tract and is widely distributed in the gastrointestinal tract, liver, kidney and lungs.[3]

Molecular Weight	310.34
Formula	C19H18O4
CAS No.	69120-06-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 225.0 mg/mL (725.0 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim YJ, et al. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba. Biol Pharm Bull. 2012;35(5):791-795. 2. Yao X, et al. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016;17(8):1199. 3. You BH, et al. Pharmacokinetic Properties of Moracin C in Mice [published correction appears in Planta Med. 2021 Feb 05;:]. Planta Med. 2021;87(8):642-651.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Obesity Compound Library Food as Medicine Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max Natural Product Library for HTS Polyphenolic Natural Product Library Selected Plant-Sourced Compound Library Traditional Chinese Medicine Monomer Library Anti-Gastroenteritis Natural Product Library Bioactive Compound Library

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Keywords

Moracin C 69120-06-5 Immunology/Inflammation ROS NO Synthase inhibitor inhibit

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