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Malvidin-3-glucoside chloride

Catalog No. TN1909 CAS 7228-78-6

Synonyms: Malvidin-3-O-glucoside chloride, Oenin chloride

Malvidin-3-glucoside chloride (Oenin chloride) has antioxidant activity, alone is not oxidized in the presence of grape polyphenol oxidase. Malvidin-3-O-glucoside chloride's color stabilization at a higher pH can be explained by self-aggregation of the flavylium cation and copigmentation with the Z-chalcone form.

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Malvidin-3-glucoside chloride Chemical Structure

Malvidin-3-glucoside chloride, CAS 7228-78-6

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Purity: 95.44%

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Description	Malvidin-3-glucoside chloride (Oenin chloride) has antioxidant activity, alone is not oxidized in the presence of grape polyphenol oxidase. Malvidin-3-O-glucoside chloride's color stabilization at a higher pH can be explained by self-aggregation of the flavylium cation and copigmentation with the Z-chalcone form.
In vitro	Here we used a gel electrophoresis assay employing supercoiled DNA plasmid to examine the ability of these compounds (1) to intercalate DNA, (2) to inhibit human topoisomerase I through both inhibition of plasmid relaxation activity (catalytic inhibition) and stabilization of the cleavable DNA-topoisomerase complex (poisoning), and (3) to inhibit or enhance oxidative single-strand DNA nicking. We found no evidence of DNA intercalation by anthocyan(id)ins in the physiological pH range for any of the compounds used in this study-cyanidin chloride, cyanidin 3-O-glucoside, cyanidin 3,5-O-diglucoside, Malvidin-3-O-glucoside chloride and luteolinidin chloride. The anthocyanins inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds.
Source	Natural Products > Ericaceae > Vaccinium

Synonyms	Malvidin-3-O-glucoside chloride, Oenin chloride
Molecular Weight	528.89
Formula	C23H25ClO12
CAS No.	7228-78-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 20 mg/ml (28.36 mM)

DMSO: 20 mg/ml (28.36 mM)

References and Literature

1. Webb MR, Min K, Ebeler SE. Anthocyanin Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions. J Food Biochem. 2008 Sep 23;32(5):576-596. 2. Wang J, et al. Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nat Commun. 2018;9(1):477. Published 2018 Feb 2.

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Keywords

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