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Loperamide hydrochloride

Catalog No. T0209 CAS 34552-83-5

Synonyms: Loperamide HCl, R-18553 (hydrochloride), ADL 2-1294

Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.

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Loperamide hydrochloride Chemical Structure

Loperamide hydrochloride, CAS 34552-83-5

Pack Size	Availability	Price/USD
100 mg	In stock	$ 50.00
500 mg	In stock	$ 77.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
Targets&IC50	μ opioid receptor:3.3 nM(Ki), δ opioid receptor:48 nM(Ki)
In vitro	In mice, ropivacaine cannot cross the blood-brain barrier. Subcutaneous injection of ropivacaine at the neck region (4 mg/kg) or at the site of tibial tumor mass (7.5-75 mg) can inhibit thermal hyperalgesia and mechanical allodynia.
In vivo	In human Chinese hamster ovary cells transfected with opioid receptors, Loperamide potently stimulates the binding of [35S]guanosine 5'-O-(3-thio)triphosphate (EC50=56 nM) and inhibits the accumulation of cAMP induced by forskolin (IC50=25 nM). Loperamide reversibly blocks the increase in intracellular calcium ([Ca2+]i) triggered by extracellular potassium ([K+]o) in a concentration-dependent manner (IC50=0.9 mM).

Synonyms	Loperamide HCl, R-18553 (hydrochloride), ADL 2-1294
Molecular Weight	513.498
Formula	C29H34Cl2N2O2
CAS No.	34552-83-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.3 mg/mL (20 mM)

Ethanol: 10.3 mg/mL (20 mM)

References and Literature

1. DeHaven-Hudkins DL, et al. J Pharmacol Exp Ther,1999, 289(1), 494-502. 2. Quinney SK, et al. J Pharmacol Exp Ther,2005, 313(3), 12011-12016. 3. Church J, et al. Mol Pharmacol,1994, 45(4), 747-757. 4. Menéndez L, et al. Pharmacol Biochem Behav. 2005 May;81(1):114-21.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library GPCR Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Bioactive Compounds Library Max Orally Active Compound Library Cardiotoxicity Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Loperamide hydrochloride 34552-83-5 Autophagy Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Loperamide Loperamide HCl R-18553 (hydrochloride) R18553 R 18553 Inhibitor ADL 2-1294 R-18553 Loperamide Hydrochloride inhibit inhibitor

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