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Lipoxamycin hemisulfate

Catalog No. T26308 CAS 11075-87-9

Synonyms: Lipoxamycin, sulfate (2:1), U-26146D, U26146D, U 26146D, Lipoxamycin

Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Lipoxamycin hemisulfate Chemical Structure

Lipoxamycin hemisulfate, CAS 11075-87-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 245.00
2 mg	In stock	$ 365.00
5 mg	In stock	$ 616.00
10 mg	In stock	$ 877.00
25 mg	In stock	$ 1,320.00
50 mg	In stock	$ 1,790.00
100 mg	In stock	$ 2,390.00

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Purity: 99.19%

Purity: 99.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.
In vitro	Lipoxamycin hemisulfate shows antifungal activity against a panel of human pathogenic fungi with better potency against some of the Candida species (MIC = 0.25-16 µg/mL)[1].
In vivo	In Chinese hamster ovary cell mutant, Lipoxamycin hemisulfate is highly toxic in mice when applied subeutaneously or topically[1].

Synonyms	Lipoxamycin, sulfate (2:1), U-26146D, U26146D, U 26146D, Lipoxamycin
Molecular Weight	843.08
Formula	C38H74N4O14S
CAS No.	11075-87-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36 mg/mL (42.7 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. S M Mandala, et al. Inhibition of Serine Palmitoyl-Transferase Activity by Lipoxamycin. J Antibiot (Tokyo). 1994 Mar;47(3):376-9. 2. Whaley HA. The structure of lipoxamycin, a novel antifungal antibiotic. J Am Chem Soc. 1971 Jul 28;93(15):3767-9. 3. Roy SK, et al. Isolation, structural elucidation and biological properties of neoenactins B1, B2, M1 and M2, neoenactin congeners. J Antibiot (Tokyo). 1987 Mar;40(3):266-74. 4. Whaley HA, Sebek OK, Lewis C. Production, isolation, characterization, and evaluation of lipoxamycin, a new antifungal agent. Antimicrob Agents Chemother (Bethesda). 1970;10:455-61.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lipoxamycin hemisulfate 11075-87-9 Microbiology/Virology Antifungal 2:1 Lipoxamycin, sulfate (2:1) Lipoxamycin, Sulfate Lipoxamycin Hemisulfate U-26146D U26146D U 26146D Lipoxamycin inhibitor inhibit

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