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Leonurine hydrochloride

Leonurine hydrochloride
Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
Catalog No. T4080Cas No. 24735-18-0
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Purity:99.47%
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Leonurine hydrochloride

Catalog No. T4080Cas No. 24735-18-0
Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$31In Stock
10 mg$48In Stock
25 mg$106In Stock
50 mg$172In Stock
100 mg$278In Stock
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Product Introduction

Bioactivity
Description
Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
In vitro
The treatment of Leonurine hydrochloride (10-50?μM) for 24?h increases apoptotic ratio from 4.9% to 11.5-61.3%, respectively. The inhibition effect of Leonurine hydrochloride on H292 cells is related to the generation of ROS and the loss of MMP. Leonurine hydrochloride can increase the phosphorylation level of p38 and reduce Akt phosphorylation. Furthermore, Leonurine hydrochloride treatment increases the expression levels of caspase-3, caspase-9 and Bax/Bcl-2[1]. In RAW 264.7 cells and mouse bone marrow monocytes (BMMs), Leonurine hydrochloride suppresses RANKL-induced osteoclastogenesis and actin ring formation in a dose-dependent manner [2].
In vivo
Leonurine hydrochloride can elevate the ET level and ET/NO ratio in rats with up-regulated ETA mRNA expression and induced abortions, but there is no change in ETB mRNA[3]. Compared with the model group, Leonurine hydrochloride treatment markedly reduces the volume of bleeding and intrauterine residual, and markedly shortens the duration of bleeding. Leonurine hydrochloride also obviously reinforces the tension and frequency of uterine contractions [4].
AliasSCM-198 hydrochloride, SCM-198 HCl
Chemical Properties
Molecular Weight347.79
FormulaC14H22ClN3O5
Cas No.24735-18-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: < 1 mg/mL (insoluble)

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