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Latanoprost

Catalog No. T2528 CAS 130209-82-4

Synonyms: Xalatan, PHXA41

Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.

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Latanoprost, CAS 130209-82-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 81.00
10 mg	In stock	$ 145.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 429.00
100 mg	In stock	$ 635.00
500 mg	In stock	$ 1,360.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.78%

Purity: 99.76%

Purity: 99.69%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.
In vitro	Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].
In vivo	Latanoprost, a clinical drug for treating primary open-angle glaucoma and intraocular hypertension, effectively ameliorates glucose and lipid disorders in two mouse models of type 2 diabetes. Its treatment improves glucose tolerance. Chronic administration of latanoprost decreases serum lipids and enhances insulin signalling in white adipose tissue and skeletal muscle. It effectually activates AMPK and regulates glucose and lipid metabolism-relevant genes in diabetic mice[2].
Cell Research	HCS cells were inoculated into a 24-well culture plate (Nunc) and cultured in 10% FBS-DMEM/F12 medium at 37°C in a humidified 5% CO2 incubator. After the cells grew into logarithmic phase, the culture medium of each culture plate well was replaced entirely with the medium containing latanoprost at concentrations varying from 50 mg/l to 0.78125 mg/l, respectively. The cells were cultured under the same condition as described earlier, and their morphology and growth status were monitored every 4 h under an Eclipse TS100 inverted microscope.(Only for Reference)

Synonyms	Xalatan, PHXA41
Molecular Weight	432.59
Formula	C26H40O5
CAS No.	130209-82-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.33 mg/mL (10 mM)

References and Literature

1. Shen JW, et al. Curr Eye Res. 2016, 17:1-8. 2. Wang G, et al. Diabetologia. 2013, 56(12):2702-12. 3. Richard L. Hébert, et al. The journal of biological chemistry.

Citations

1. Wu S, Liu C, Tang J, et al.Tafluprost promotes axon regeneration after optic nerve crush via Zn2+-mTOR pathway.Neuropharmacology.2023: 109746.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library GPCR Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Approved Drug Library Endocrinology-Hormone Compound Library Metabolism Compound Library Transcription Factor-Targeted Compound Library Anti-Hypertension Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Latanoprost 130209-82-4 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Metabolism Prostaglandin Receptor GPR RAR/RXR Xalatan PHXA41 PHXA 41 Inhibitor PHXA-41 inhibit inhibitor

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