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LTX315 acetate

Catalog No. T6881L

Synonyms: KKWWKKW-Dip-K-NH2 acetate, Oncopore acetate, Ruxotemitide acetate, LTX315 acetate(1345407-05-7, Free base)

LTX315 acetate (Oncopore acetate) is an oncolytic peptide with potent anticancer activity, with IC50 values of 34.3 µM for MRC-5, 8.3 µM for A20, and 11 µM for AT84, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LTX315 acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
2 mg	In stock	$ 97.00
5 mg	In stock	$ 139.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 467.00
50 mg	In stock	$ 685.00
100 mg	In stock	$ 975.00

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LTX315 acetate (Oncopore acetate) is an oncolytic peptide with potent anticancer activity, with IC50 values of 34.3 µM for MRC-5, 8.3 µM for A20, and 11 µM for AT84, respectively.
Targets&IC50	A20:8.3 µM, AT84:11 µM, MRC5:34.3 µM
In vitro	LTX315 acetate induces rapid killing of cancer cells. LTX315 acetate is equally potent against drug-resistant cancer cells, non-toxic to erythrocytes, shows high plasma protein binding, and can be rapidly degraded to non-toxic metabolites. The oncolytic activity of LTX315 acetate results from direct lysis of the plasma membrane and permeabilization of the mitochondrial membrane, resulting in cell death due to necrosis and release of tumor antigens. Treatment of cancer cells with LTX315 acetate results in the release of several danger signals (DAMPs) that are associated with immunogenic cell death and stimulation of adaptive immune responses[1].
In vivo	Intratumoral administration of LTX315 acetate resulted in tumor necrosis and immune cell infiltration into the tumor parenchyma, followed by complete tumor regression in most animals. LTX-315 induces the release of risk-associated molecular patterning molecules, such as high mobility group box-1 proteins, in vitro, followed by upregulation of pro-inflammatory cytokines such as interleukin (IL) 1β, IL6, and IL18 in vivo. Animals cured by LTX315 acetate treatment were protected from rechallenging with live intradermal and intravenous B16 tumor cells [2].

Synonyms	KKWWKKW-Dip-K-NH2 acetate, Oncopore acetate, Ruxotemitide acetate, LTX315 acetate(1345407-05-7, Free base)
Molecular Weight	1499.84
Formula	C80H110N18O11

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Haug BE, et al. Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. 2. Camilio KA, et al. Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315. Cancer Immunol Immunother. 2014 Jun;63(6):601-13.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Peptide Compound Library Anti-Cancer Clinical Compound Library Anti-Breast Cancer Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LTX315 acetate Others Ruxotemitide Acetate LTX-315 acetate KKWWKKW-Dip-K-NH2 acetate Oncopore acetate LTX-315 Acetate Ruxotemitide acetate LTX315 acetate(1345407-05-7, Free base) LTX 315 Acetate KKWWKKW-Dip-K-NH2 Acetate Oncopore Acetate LTX315 Acetate inhibitor inhibit

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