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K858 (Racemic)

Catalog No. T3120 CAS 72926-24-0

Synonyms: K858 Racemic, K858

K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.

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K858 (Racemic), CAS 72926-24-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 159.00
50 mg	In stock	$ 288.00
100 mg	In stock	$ 513.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
Targets&IC50	EG5:1.3 μM
In vitro	K858 is an ATP-uncompetitive inhibitor of Eg5 that is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 induces mitotic arrest and growth inhibition through the activation of the Mad2-mediated spindle checkpoint. K858 induces mitotic cell death in Y cells but not in normal cells. K858 induces mitotic arrest, apoptosis, and cell growth inhibition and has no effect on microtubule polymerization.
In vivo	K858 exhibits antitumor activity and induces mitotic arrest in a human tumor xenograft mouse model. K858 exhibits antitumor activity and induces mitotic arrest in human xenograft tumor models. [1]

Synonyms	K858 Racemic, K858
Molecular Weight	277.34
Formula	C13H15N3O2S
CAS No.	72926-24-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.7 mg/mL(100 mM)

References and Literature

1. Nakai R, et al. Y Res. 2009 May 1;69(9):3901-9. 2. Indorato RL, et al. Biochem Pharmacol. 2013 Nov 15;86(10):1441-51.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library Apoptosis Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library NO PAINS Compound Library Cytoskeletal Signaling Pathway Compound Library

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Keywords

K858 (Racemic) 72926-24-0 Apoptosis Cytoskeletal Signaling Kinesin inhibit K858 Racemic Inhibitor K-858 (Racemic) K 858 K-858 K858 Racemic inhibitor

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